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Thiazolidines derivatives and their anti-inflammatory activity in LPS-induced RAW 264.7 macrophages: a systematic review and meta-analysis.
Bramorski Mohr, Eduarda Talita; Lubschinski, Tainá Larissa; Oliveira, Júlia Meller Dias de; Giarola Fragoso de Oliveira, Paula; Garcia Mendes Borba, Beatriz; Demarchi, Izabel Galhardo; Dalmarco, Eduardo Monguilhott.
Afiliação
  • Bramorski Mohr ET; Postgraduate Program in Pharmacy (PPGFar), Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis, Brazil.
  • Lubschinski TL; Postgraduate Program in Pharmacy (PPGFar), Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis, Brazil.
  • Oliveira JMD; Department of Dentistry, Brazilian Centre for Evidence-Based Research (COBE), Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.
  • Giarola Fragoso de Oliveira P; Postgraduate Program in Pharmacy (PPGFar), Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis, Brazil.
  • Garcia Mendes Borba B; Postgraduate Program in Pharmacy (PPGFar), Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis, Brazil.
  • Demarchi IG; Department of Clinical Analysis, Center of Health Sciences, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis, Brazil.
  • Dalmarco EM; Postgraduate Program in Pharmacy (PPGFar), Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis, Brazil.
Nat Prod Res ; : 1-17, 2024 Aug 21.
Article em En | MEDLINE | ID: mdl-39165196
ABSTRACT
Thiazolidine scaffolds have been investigated for decades, due to their wide range of biological activity. In this way, the main objective of this systematic review was to elucidate the anti-inflammatory activity of thiazolidine derivatives against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. From 9718 identified registers, 13 articles were included, where 11 studies evaluated thiazolidinediones. The summary of relevance demonstrated that seven studies (53.8%) were relevant without restrictions, and 6 (46.2%) were relevant with restrictions. The certainty in cumulative evidence was considered moderate and the six studies included in the meta-analysis demonstrated the positive activity of thiazolidinediones against NO production when compared to the negative LPS control.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido