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Efficient Synthesis and Iodine-Functionalization of Pyrazoles via KIO3/PhSeSePh System under Acidic Conditions.
Peglow, Thiago J; Thomaz, João Pedro S S C; Nobre, Patrick C; Scimmi, Cecilia; Santi, Claudio; Nascimento, Vanessa.
Afiliação
  • Peglow TJ; SupraSelen Laboratory, Department of Chemistry, Federal University Fluminense, Institute of Chemistry, Campus do Valonguinho, 24020-141, Niterói-RJ, Brazil.
  • Thomaz JPSSC; SupraSelen Laboratory, Department of Chemistry, Federal University Fluminense, Institute of Chemistry, Campus do Valonguinho, 24020-141, Niterói-RJ, Brazil.
  • Nobre PC; SupraSelen Laboratory, Department of Chemistry, Federal University Fluminense, Institute of Chemistry, Campus do Valonguinho, 24020-141, Niterói-RJ, Brazil.
  • Scimmi C; Group of Catalysis, Synthesis and OrganicGreen Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
  • Santi C; Group of Catalysis, Synthesis and OrganicGreen Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
  • Nascimento V; SupraSelen Laboratory, Department of Chemistry, Federal University Fluminense, Institute of Chemistry, Campus do Valonguinho, 24020-141, Niterói-RJ, Brazil.
Chem Asian J ; : e202400749, 2024 Aug 20.
Article em En | MEDLINE | ID: mdl-39163199
ABSTRACT
This manuscript reports a novel method for the direct iodination of the C-4 pyrazole ring generated in situ by the reaction of 1,1,3,3-tetramethoxypropane and various hydrazines. In this approach, potassium iodate (KIO3) is used as the iodinating agent and (PhSe)2 is used as catalysts under acidic conditions. This protocol provides a convenient method for the efficient synthesis of 4-iodo-1-aryl-1H-pyrazoles, valuable intermediates for several different coupling reactions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Asian J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Asian J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha