Mycobolome of Phialomyces macrosporus across OSMAC-based assorted culture media.

Geris, Regina; de Jesus, Vitória Evelyn Teles; Alvarenga, Yasmin; Boffo, Elisangela F

Geris, Regina; de Jesus, Vitória Evelyn Teles; Alvarenga, Yasmin; Boffo, Elisangela F.

Afiliação

Geris R; Universidade Federal da Bahia, Organic chemistry, UFBA- Campus Universitário de Ondina, Instituto de Química - DQO, Rua Barão de Geremoabo, s/n, Ondina, 4141098040, Salvador, BRAZIL.
de Jesus VET; Federal University of Bahia, Institute of Chemistry, Rua Barão de Geremoabo s/n, 40170-290, Salvador, BRAZIL.
Alvarenga Y; Federal University of Bahia, Chemistry, Rua Barão de Geremoabo s/n, 40170-290, Salvador, BRAZIL.
Boffo EF; Federal University of Bahia, Institute of Chemistry, Rua Barão de Geremoabo s/n, 40170-290, Salvador, BRAZIL.

Chem Biodivers ; : e202401547, 2024 Aug 13.

Article em En | MEDLINE | ID: mdl-39136586

ABSTRACT

ABSTRACT

The fungus Phialomyces macrosporus was cultured using the One Strain Many Compounds (OSMAC) strategies to evaluate its metabolome. Variations in the nutrient culture media, culture regime, and cultivation parameters can significantly influence fungal extract quantity and chemical diversity. This study aimed to explore the mycobolome of P. macrosporus in five different culture media and two different cultivation conditions using NMR-based metabolomics. Principal component analysis (PCA) of 1H NMR spectra revealed clear differentiation between these samples, highlighting the rice dextrose agar medium (RDA) and potato dextrose broth (PDB) as standard complex media for conducting a fungal metabolite screening program.

Palavras-chave

OSMAC approach; OSMAC-NMR-PCA; Phialomyces macrosporus; metabolite profiling; mycobolome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça

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