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Assessment of Biochemical, Inflammatory Biomarkers and Ultra-Processed Food Consumption in Children with Small Intestinal Bacterial Overgrowth: A Cross-Sectional Study.
Costa, Paulo César Trindade; Duarte, Davyson Barbosa; Viana das Neves, Thallyta Alanna Ferreira; Moraes, Rúbia Cartaxo Squizato de; Toscano, Lydiane de Lima Tavares; Arruda Neta, Adélia da Costa Pereira de; Baccin Martins, Vinicius José; de Brito Alves, José Luiz.
Afiliação
  • Costa PCT; Department of Nutrition, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
  • Duarte DB; Department of Nutrition, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
  • Viana das Neves TAF; Department of Nutrition, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
  • Moraes RCS; Department of Nutrition, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
  • Toscano LLT; Department of Nutrition, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
  • Arruda Neta ADCP; Department of Nutrition, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
  • Baccin Martins VJ; Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.
  • de Brito Alves JL; Department of Nutrition, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
Nutrients ; 16(15)2024 Jul 31.
Article em En | MEDLINE | ID: mdl-39125359
ABSTRACT

OBJECTIVE:

This study evaluated anthropometric, biochemical, and inflammatory biomarkers, as well as dietary intake in Brazilian children diagnosed with small intestinal bacterial overgrowth (SIBO) and compared them with their counterparts without SIBO.

METHODS:

This was a cross-sectional study with 106 children aged 7 to 10 years. A glucose-hydrogen breath test was performed to diagnose small intestinal bacterial overgrowth (SIBO). Anthropometric and dietary characteristics were assessed. Blood samples were collected and serum biochemical parameters and cytokines were measured.

RESULTS:

The occurrence of SIBO was 13.2%. Age, BMI, BMI/age WC, BFP, sex and biochemical markers were similar between SIBO-positive and SIBO-negative children (p > 0.05). High consumption of ultra-processed foods tended to be higher in SIBO-positive compared to SIBO-negative children (47.8 ± 8.2 vs. 42.6 ± 9.5, p = 0.06). Serum levels of IL-17 were higher in SIBO-positive than in SIBO-negative children [69.5 (5.4-125.7) vs. 53.4 (2.3-157.7), p = 0.03], while serum levels of IL-10 were lower in SIBO-positive than in SIBO-negative children [2.3 (0.6-7.2) vs. 5.7 (0.5-30.8), p = 0.04]. Finally, in a logistic regression adjusted for sex, BMI and age, consumption of ultra-processed foods (p = 0.03) and IL-6 levels (p = 0.003) were found to contribute to the occurrence of SIBO.

CONCLUSION:

this study identified for the first time an occurrence of 13% of SIBO in children living in the northeastern region of Brazil and showed that consumption of ultra-processed foods and serum levels of IL-6 may influence the occurrence of the SIBO in the pediatrics population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Alimento Processado / Intestino Delgado Limite: Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Alimento Processado / Intestino Delgado Limite: Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça