Comparative Study of Antioxidant Activity of Dextran-Coated Iron Oxide, Gold, and Silver Nanoparticles Against Age-Induced Oxidative Stress in Erythrocytes.

Yadav, Somu; Bhagat, Stuti; Singh, Sanjay; Maurya, Pawan Kumar

Yadav, Somu; Bhagat, Stuti; Singh, Sanjay; Maurya, Pawan Kumar.

Afiliação

Yadav S; Department of Biochemistry, Central University of Haryana, Mahendergarh, India.
Bhagat S; DBT-National Institute of Animal Biotechnology (NIAB), Hyderabad, Telangana, India.
Singh S; DBT-Regional Centre for Biotechnology (RCB), Faridabad, Haryana, India.
Maurya PK; DBT-National Institute of Animal Biotechnology (NIAB), Hyderabad, Telangana, India.

J Gerontol A Biol Sci Med Sci ; 79(11)2024 Nov 01.

Article em En | MEDLINE | ID: mdl-39120090

ABSTRACT

ABSTRACT

Erythrocytes undergo several changes during human aging and age-related diseases and, thus, have been studied as biomarkers of the aging process. The present study aimed to explore the antioxidant ability of metal and metal oxide nanoparticles (NPs) such as iron oxide (Fe3O4), gold (Au), and silver (Ag) to mitigate age-related oxidative stress in human erythrocytes. Metal and metal oxide NPs behave like antioxidative enzymes, directly influencing redox pathways and thus have better efficiency. Additionally, biopolymer coatings such as dextran enhance the biocompatibility of these NPs. Therefore, dextran-coated Fe3O4, Au, and Ag NPs were synthesized using wet chemical methods and were characterized. Their hemocompatibility and ability to protect erythrocytes from age-induced oxidative stress were investigated. The Fe3O4 and Au NPs were observed to protect erythrocytes from hydrogen peroxide and age-induced oxidative damage, including decreased antioxidant levels, reduced activity of antioxidative enzymes, and increased amounts of oxidative species. Pretreatment with NPs preserved the morphology and membrane integrity of the erythrocyte. However, Ag NPs induced oxidative stress in erythrocytes similar to hydrogen peroxide. Therefore, dextran-coated Fe3O4 and Au nanoparticles have the potential to be employed as antioxidant therapies against age-related oxidative stress.

Assuntos

Antioxidantes; Dextranos; Eritrócitos; Ouro; Nanopartículas Metálicas; Estresse Oxidativo; Prata; Estresse Oxidativo/efeitos dos fármacos; Humanos; Eritrócitos/efeitos dos fármacos; Eritrócitos/metabolismo; Dextranos/farmacologia; Prata/farmacologia; Antioxidantes/farmacologia; Ouro/farmacologia; Compostos Férricos/farmacologia; Envelhecimento/efeitos dos fármacos; Envelhecimento/metabolismo; Peróxido de Hidrogênio/metabolismo

Palavras-chave

Aging; Antioxidant-like activity, Erythrocytes; Nanoparticles; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prata / Dextranos / Estresse Oxidativo / Eritrócitos / Nanopartículas Metálicas / Ouro / Antioxidantes Limite: Humans Idioma: En Revista: J Gerontol A Biol Sci Med Sci Assunto da revista: GERIATRIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia País de publicação: Estados Unidos

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