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Associations of oxidative stress markers with the prevalence of sarcopenia in the United States general population.
Sang, Tingting; Gao, Feng; Lu, Xiao; Yang, Ying; Liu, Lingling; Zhang, Gang; Han, Guosong.
Afiliação
  • Sang T; Department of Rehabilitation, The People's Hospital of Suzhou New District, Suzhou, Jiangsu, China.
  • Gao F; Department of Orthopedics, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu, China.
  • Lu X; Department of Rehabilitation, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Nanjing, Jiangsu, China.
  • Yang Y; Department of Rehabilitation, The People's Hospital of Suzhou New District, Suzhou, Jiangsu, China.
  • Liu L; Department of Rehabilitation, The First Affiliated Hospital of Anhui Medical University, Shushan District, Hefei, Anhui, China.
  • Zhang G; Department of Rehabilitation, The First Affiliated Hospital of Anhui Medical University, Shushan District, Hefei, Anhui, China.
  • Han G; Department of Orthopaedics, The First People's Hospital of Hefei City, Hefei, Anhui, China. Electronic address: hanguosong137@163.com.
Clinics (Sao Paulo) ; 79: 100450, 2024.
Article em En | MEDLINE | ID: mdl-39096855
ABSTRACT

OBJECTIVE:

The purpose of the present study was to examine the association of oxidative stress markers with sarcopenia in the general United States population under the age of 60.

METHODS:

We used the National Health and Nutrition Examination Survey data from 2011‒2014 and performed Restricted Cubic Spline (RCS) plots, weighted multivariable logistic regression analysis to calculate ratio ratios and 95% Confidence Intervals, and subgroup analysis based on age, sex, hypertension, diabetes mellitus, and body mass index stratification to determine the association of markers of oxidative stress with the prevalence of sarcopenia.

RESULTS:

The present analysis included a total of 8,782 participants. Firstly, the RCS plots showed a roughly L-shaped curve association of total bilirubin and serum iron with a prevalence of sarcopenia. Secondly, albumin was negatively and linearly associated with the risk of sarcopenia. Finally, with the increase in gamma-glutamyl transferase, the prevalence of sarcopenia showed a trend of first rising and then declining as a result of the iron increase.

CONCLUSIONS:

We demonstrated a nonlinear association between markers of oxidative stress and sarcopenia. The need to focus more on levels of oxidative stress in the body could provide better prevention strategies for sarcopenia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Inquéritos Nutricionais / Estresse Oxidativo / Sarcopenia Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Inquéritos Nutricionais / Estresse Oxidativo / Sarcopenia Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos