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Biliary stenosis after liver transplant is not associated with cytomegalovirus infection.
Castro, Juliano Félix; Souza, Ana Cláudia; de Faria Andrade, Antônio Márcio; Corrêa, Henrique Peragallos; Athanasio, Bruno da Silva; Lima, Cristiano Xavier.
Afiliação
  • Castro JF; Division of Hepatobiliary Surgery, Department of Surgery, School of Medicine of the Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Souza AC; Transplant Unit, Felicio Rocho Hospital, Belo Horizonte, Brazil.
  • de Faria Andrade AM; Transplant Unit, Felicio Rocho Hospital, Belo Horizonte, Brazil.
  • Corrêa HP; Division of Hepatobiliary Surgery, Department of Surgery, School of Medicine of the Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Athanasio BDS; Transplant Unit, Felicio Rocho Hospital, Belo Horizonte, Brazil.
  • Lima CX; Transplant Unit, Felicio Rocho Hospital, Belo Horizonte, Brazil.
Transl Gastroenterol Hepatol ; 9: 34, 2024.
Article em En | MEDLINE | ID: mdl-39091648
ABSTRACT

Background:

Liver transplantation (LT) is the best treatment for end-stage liver disease; however, biliary complications (BCs) still pose a significant challenge. Among the post-transplant BC, strictures and biliary fistulas are the most common. Biliary strictures are classified as anastomotic and non-anastomotic. Some previous studies suggest an association between post-transplant biliary strictures and cytomegalovirus (CMV) infection. In this study, we aimed to identify whether there is an association between CMV infection and biliary strictures in patients undergoing LT.

Methods:

A retrospective study of 175 patients aged ≥18 years undergoing LT at Felicio Rocho Hospital between 2011 and 2017 was conducted. All included patients received grafts perfused with Institut Georges Lopez-1 (IGL-1) solution from brain-dead donors, survived post-transplantation for more than 120 days, and had a minimum follow-up of 12 months after LT. The diagnosis of CMV was made by antigenemia and biliary strictures by magnetic resonance cholangiopancreatography (MRCP).

Results:

The average age of the recipients was 54 years. Postoperative BCs occurred in 12% of transplants. The most common BC was stricture (9.1%), with a predominance of anastomotic strictures (AS) over non-AS (NAS) (87.5% vs. 12.5%, respectively). CMV infection was confirmed in 22.9% of patients. In the univariate analysis, post-transplant CMV infection correlated with the development of BCs (P=0.01), as well as biliary strictures (P=0.008). In the multivariate analysis, however, only model for end-stage liver disease (MELD) >21 was a risk factor for the development of BCs in general (P=0.02) and biliary strictures (P=0.01).

Conclusions:

CMV infection was not an independent risk factor for the development of non-anastomotic post-transplant biliary strictures in this study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Transl Gastroenterol Hepatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Transl Gastroenterol Hepatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: China