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Correlation of serum Klotho, fetuin-A, and MGP levels with coronary artery calcification in maintenance hemodialysis patients.
Wang, Dan; Chu, XiuLin; Cao, JuHua; Peng, YunHua.
Afiliação
  • Wang D; Department of East Hospital Nephrology, Yantaishan Hospital, Yantai City, Shandong Province, China.
  • Chu X; Department of Nephrology, The People's Hospital of Xushui, Baoding City, Hebei Province, China.
  • Cao J; Department of Outpatient, The General Hospital of Western Theater Command of Chinese people's liberation army, Chengdu City, Sichuan Province, China.
  • Peng Y; Department of Nephrology, Dafeng People's Hospital, Yancheng City, JiangSu Province, China. Electronic address: wanglei_1346_gphc@hotmail.com.
Clinics (Sao Paulo) ; 79: 100417, 2024.
Article em En | MEDLINE | ID: mdl-39089098
ABSTRACT

OBJECTIVE:

This study was to investigate the role of serum Klotho, fetuin-A, and Matrix Gla Protein (MGP) in Coronary Artery Calcification (CAC) in patients with Maintenance Hemodialysis (MHD) and their predictive value for CAC.

METHODS:

100 patients receiving MHD were selected. Serum Klotho, fetuin-A, and MGP levels were detected by ELISA. CAC scores were assessed by coronary CT scan. Multifactor analysis was used to evaluate the risk factors affecting CAC. The ability of serum Klotho, fetuin-A, and MGP levels to diagnose CAC was evaluated by receiver operating characteristic curves.

RESULTS:

Serum Klotho, fetuin-A, and MGP were independent risk factors for CAC. Serum Klotho, fetuin-A, and MGP were valuable in the diagnosis of CAC in MHD patients.

CONCLUSION:

There is a close relationship between Klotho, fetuin-A, and MGP levels in MHD patients and CAC.
Assuntos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Proteínas de Ligação ao Cálcio / Biomarcadores / Proteínas da Matriz Extracelular / Diálise Renal / Calcificação Vascular / Alfa-2-Glicoproteína-HS / Proteínas Klotho / Proteína de Matriz Gla / Glucuronidase Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Proteínas de Ligação ao Cálcio / Biomarcadores / Proteínas da Matriz Extracelular / Diálise Renal / Calcificação Vascular / Alfa-2-Glicoproteína-HS / Proteínas Klotho / Proteína de Matriz Gla / Glucuronidase Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos