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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin.
Zheng, Meifeng; Zhang, Borui; Yau, Sonata S Y; So, Kwok-Fai; Zhang, Li; Ou, Haining.
Afiliação
  • Zheng M; Department of Rehabilitation Medicine, Guangzhou Medical University, Guangzhou, Guangdong Province, China.
  • Zhang B; Department of Rehabilitation Medicine, The Fifth Clinical College of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
  • Yau SSY; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China.
  • So KF; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China.
  • Zhang L; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
  • Ou H; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China.
Neural Regen Res ; 20(5): 1445-1454, 2025 May 01.
Article em En | MEDLINE | ID: mdl-39075911
ABSTRACT
JOURNAL/nrgr/04.03/01300535-202505000-00027/figure1/v/2024-07-28T173839Z/r/image-tiff Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy. Physical exercise enhances neurogenesis and synaptogenesis, and has been widely used for functional rehabilitation after stroke. In this study, we determined whether exercise training before disease onset can alleviate the severity of cerebral ischemia. We also examined the role of exercise-induced circulating factors in these effects. Adult mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery occlusion. We found that this exercise pre-conditioning strategy effectively attenuated brain infarct area, inhibited gliogenesis, protected synaptic proteins, and improved novel object and spatial memory function. Further analysis showed that circulating adiponectin plays a critical role in these preventive effects of exercise. Agonist activation of adiponectin receptors by AdipoRon mimicked the effects of exercise, while inhibiting receptor activation abolished the exercise effects. In summary, our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Neural Regen Res Ano de publicação: 2025 Tipo de documento: Article País de afiliação: China País de publicação: Índia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Neural Regen Res Ano de publicação: 2025 Tipo de documento: Article País de afiliação: China País de publicação: Índia