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Acylcarnitines are associated with lower depressive symptomatology in a mainland puerto rican cohort.
Palacios, Natalia; Bhupathiraju, Shilpa N; Kelly, Rachel S; Lee, Jong Soo; Ordovas, Jose M; Tucker, Katherine L.
Afiliação
  • Palacios N; Department of Public Health, University of Massachusetts Lowell, 61 Wilder Street, Suite 540-K, Lowell, MA, 01854, USA. natalia_palacios@uml.edu.
  • Bhupathiraju SN; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. natalia_palacios@uml.edu.
  • Kelly RS; Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, USA. natalia_palacios@uml.edu.
  • Lee JS; Center for Population Health, University of Massachusetts Lowell, Lowell, MA, USA. natalia_palacios@uml.edu.
  • Ordovas JM; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
  • Tucker KL; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Metabolomics ; 20(4): 85, 2024 Jul 27.
Article em En | MEDLINE | ID: mdl-39066829
ABSTRACT

INTRODUCTION:

Recent studies have implicated acetyl-L-carnitine as well as other acylcarnitines in depression. To our knowledge, no untargeted metabolomics studies have been conducted among US mainland Puerto Ricans.

OBJECTIVES:

We conducted untargeted metabolomic profiling on plasma from 736 participants of the Boston Puerto Rican Health Study.

METHODS:

Using Weighted Gene Co-expression Network Analysis, we identified metabolite modules associated with depressive symptomatology, assessed via the Center for Epidemiologic Studies Depression scale. We identified metabolites contributing to these modules and assessed the relationship between these metabolites and depressive symptomatology.

RESULTS:

621 annotated metabolites clustered into eight metabolite modules, of which one, the acylcarnitine module, was significantly inversely associated with depressive symptomatology (ß = - 27.7 (95% CI (- 54.5-0.8); p = 0.043). Several metabolite hub features in the acylcarnitine module were significantly associated with depressive symptomatology, after correction for multiple comparisons.

CONCLUSIONS:

In this untargeted plasma metabolomics study among mainland Puerto Rican older adults, acylcarnitines, as a metabolite module were inversely associated with depressive symptomatology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina / Depressão / Metabolômica Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte / Caribe / Puerto rico Idioma: En Revista: Metabolomics Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina / Depressão / Metabolômica Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte / Caribe / Puerto rico Idioma: En Revista: Metabolomics Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos