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The Effect of Broccoli Glucosinolates Hydrolysis Products on Botrytis cinerea: A Potential New Antifungal Agent.
Román, Juan; Lagos, Ailine; Mahn, Andrea; Quintero, Julián.
Afiliação
  • Román J; Department of Chemical Engineering, University of Santiago, Chile, Avenida Libertador Bernardo O'Higgins 3363, Estación Central, Santiago 9170019, Chile.
  • Lagos A; Department of Chemical Engineering, University of Santiago, Chile, Avenida Libertador Bernardo O'Higgins 3363, Estación Central, Santiago 9170019, Chile.
  • Mahn A; Department of Chemical Engineering, University of Santiago, Chile, Avenida Libertador Bernardo O'Higgins 3363, Estación Central, Santiago 9170019, Chile.
  • Quintero J; Department of Chemical Engineering, University of Santiago, Chile, Avenida Libertador Bernardo O'Higgins 3363, Estación Central, Santiago 9170019, Chile.
Int J Mol Sci ; 25(14)2024 Jul 20.
Article em En | MEDLINE | ID: mdl-39063186
ABSTRACT
The present study investigates the interactions between eight glucosinolate hydrolysis products (GHPs) sourced from broccoli by-products and the detoxifying enzymes of Botrytis cinerea, namely eburicol 14-alpha-demethylase (CYP51) and glutathione-S-transferase (GST), through in silico analysis. Additionally, in vitro assays were conducted to explore the impact of these compounds on fungal growth. Our findings reveal that GHPs exhibit greater efficacy in inhibiting conidia germination compared to mycelium growth. Furthermore, the results demonstrate the antifungal activity of glucosinolate hydrolysis products derived from various parts of the broccoli plant, including inflorescences, leaves, and stems, against B. cinerea. Importantly, the results suggest that these hydrolysis products interact with the detoxifying enzymes of the fungus, potentially contributing to their antifungal properties. Extracts rich in GHPs, particularly iberin and indole-GHPs, derived from broccoli by-products emerge as promising candidates for biofungicidal applications, offering a sustainable and novel approach to plant protection by harnessing bioactive compounds from agricultural residues.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Brassica / Botrytis / Glucosinolatos / Antifúngicos Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Brassica / Botrytis / Glucosinolatos / Antifúngicos Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Suíça