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Different immunological patterns of Down syndrome patients with and without recurrent infections.
Martins, Kamila Rosa; Alves, Flavia Araujo; Silva, Luiz Roberto da; Silva, Lauren Olivia Alves da; Segundo, Gesmar Rodrigues Silva.
Afiliação
  • Martins KR; Universidade Federal de Uberlândia, Hospital de Clínicas, Uberlândia, MG, Brazil.
  • Alves FA; Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
  • Silva LRD; Universidade Federal de Uberlândia, Faculdade de Medicina, Departamento de Pediatria, Uberlândia, MG, Brazil.
  • Silva LOAD; Universidade Federal de Uberlândia, Faculdade de Medicina, Departamento de Pediatria, Uberlândia, MG, Brazil.
  • Segundo GRS; Universidade Federal de Uberlândia, Faculdade de Medicina, Departamento de Pediatria, Uberlândia, MG, Brazil. Electronic address: gesmar@ufu.br.
J Pediatr (Rio J) ; 100(6): 653-659, 2024.
Article em En | MEDLINE | ID: mdl-39053889
ABSTRACT

OBJECTIVE:

Individuals with Down Syndrome (DS) exhibit a higher susceptibility to infections, suggesting potential immunological alterations within this population. Consequently, this study aims to assess the immune response profile in children with DS to identify potential immune dysfunctions associated with recurrent infections.

METHODS:

The authors conducted a retrospective analysis involving 49 DS patients, examining various epidemiological, clinical, cytogenetic, and laboratory variables. The study's sample comprised patients aged 2-20 years, with a predominance of males. These patients were categorized into two groups based on the presence or absence of recurrent infections, as indicated by the Jeffrey Modell Foundation alert signs.

RESULTS:

Immunoglobulin (Ig) A, G, and M levels were deemed normal, although individuals with DS experiencing recurrent infections exhibited significantly lower IgA levels. Additionally, CD3, CD4, CD8, and CD19 lymphocyte counts were found to be within normal ranges, with no significant differences between the two groups. While overall data indicated normal seroconversion levels of pneumococcal polysaccharide antibodies, a notable impairment in seroconversion was observed among DS patients with recurrent infections compared to those without such infections.

CONCLUSION:

The deficiency of anti-polysaccharide antibodies in individuals with DS may constitute an important immunological comorbidity. Therefore, it warrants further investigation, particularly among individuals with recurrent infections.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recidiva / Síndrome de Down Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recidiva / Síndrome de Down Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil