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Mild hyperbaric oxygen exposure protects heart during ischemia/reperfusion and affects vascular relaxation.
Gutierrez, Christopher; Peirone, Magdalena; Carranza, Andrea; Di Girolamo, Guillermo; Bonazzola, Patricia; Castilla, Rocío.
Afiliação
  • Gutierrez C; Instituto Alberto C Taquini de Investigaciones en Medicina Traslacional (IATIMET), CONICET, Universidad de Buenos Aires, Marcelo T. de Alvear 2270, Ciudad Autónoma de Buenos Aires, C1122AAJ, Argentina.
  • Peirone M; Instituto Alberto C Taquini de Investigaciones en Medicina Traslacional (IATIMET), CONICET, Universidad de Buenos Aires, Marcelo T. de Alvear 2270, Ciudad Autónoma de Buenos Aires, C1122AAJ, Argentina.
  • Carranza A; Cátedra de Farmacología, Departamento de Farmacología, Facultad de Farmacia y Bioquímica, CONICET, Universidad de Buenos Aires, Junín 956, C1113AAD, Ciudad Autónoma de Buenos Aires, Argentina.
  • Di Girolamo G; Instituto Alberto C Taquini de Investigaciones en Medicina Traslacional (IATIMET), CONICET, Universidad de Buenos Aires, Marcelo T. de Alvear 2270, Ciudad Autónoma de Buenos Aires, C1122AAJ, Argentina.
  • Bonazzola P; Instituto Alberto C Taquini de Investigaciones en Medicina Traslacional (IATIMET), CONICET, Universidad de Buenos Aires, Marcelo T. de Alvear 2270, Ciudad Autónoma de Buenos Aires, C1122AAJ, Argentina.
  • Castilla R; Instituto Alberto C Taquini de Investigaciones en Medicina Traslacional (IATIMET), CONICET, Universidad de Buenos Aires, Marcelo T. de Alvear 2270, Ciudad Autónoma de Buenos Aires, C1122AAJ, Argentina. rcastillalozano@fmed.uba.ar.
Pflugers Arch ; 476(10): 1587-1595, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39052036
ABSTRACT
Mild hyperbaric oxygen therapy (mHBOT) is an adjuvant therapy used in conditions where tissue oxygenation is reduced and is implemented using pressures less than 1.5 ATA and 100% O2 (instead of the classical HBOT at 1.9-3 ATA) which results in cheaper, easier to implement, and equally effective. mHBOT is offered for wellness and beauty and as an anti-aging strategy, in spite of the absence of studies on the cardiovascular system. Consequently, we investigated the impact of mHBOT on the cardiovascular system. Mechanical and energetic parameters of isolated heart submitted to ischemia/reperfusion injury and arterial contractile response from mHBOT-exposed rats were evaluated. In the heart, mHBOT increased pre-ischemic velocity of contraction and ischemic end-diastolic pressure and developed pressure and contractile economy during reperfusion. mHBOT decreased infarct size and increased the plasma nitrite levels. In the artery, mHBOT increased acetylcholine sensitivity. mHBOT protects the heart during ischemia/reperfusion and affects vascular relaxation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasodilatação / Traumatismo por Reperfusão Miocárdica / Ratos Wistar / Oxigenoterapia Hiperbárica Limite: Animals Idioma: En Revista: Pflugers Arch Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasodilatação / Traumatismo por Reperfusão Miocárdica / Ratos Wistar / Oxigenoterapia Hiperbárica Limite: Animals Idioma: En Revista: Pflugers Arch Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha