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Analgesia by fascia manipulation is mediated by peripheral and spinal adenosine A1 receptor in a mouse model of peripheral inflammation.
Eugenia Ortiz, Maria; Sinhorim, Larissa; Hoffmann de Oliveira, Bruna; Hardt da Silva, Rafaela; Melo de Souza, Gabriel; de Souza, Gabriela; Paula Piovezan, Anna; Balduino Bittencourt, Edsel; Bianco, Gianluca; Shiguemi Inoue Salgado, Afonso; Klingler, Werner; Schleip, Robert; Fernandes Martins, Daniel.
Afiliação
  • Eugenia Ortiz M; Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
  • Sinhorim L; Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
  • Hoffmann de Oliveira B; Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
  • Hardt da Silva R; Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
  • Melo de Souza G; Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
  • de Souza G; Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
  • Paula Piovezan A; Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
  • Balduino Bittencourt E; Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil; Coastal Health Institute, Jacksonville, USA.
  • Bianco G; Research Laboratory of Posturology and Neuromodulation (RELPON), Department of Human Neuroscience, Sapienza University, Rome, Italy; Istituto di Formazione in Agopuntura e Neuromodulazione (IFAN), Roma, Italy.
  • Shiguemi Inoue Salgado A; Natural Quanta Wellness Center, Windermere, USA.
  • Klingler W; SRH Hospitals, Sigmaringen, Germany; Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany; Department for Medical Professions, Diploma University of Applied Sciences, Bad Sooden-Allendorf, Germany.
  • Schleip R; Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany; Department for Medical Professions, Diploma University of Applied Sciences, Bad Sooden-Allendorf, Germany; Fascia Research Group, Experimental Anesthesiology, Ulm University, Ulm, Germany.
  • Fernandes Martins D; Experimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil. Electronic address: danielmartinsfisio@hotmail.com.
Neuroscience ; 555: 125-133, 2024 Sep 13.
Article em En | MEDLINE | ID: mdl-39038598
ABSTRACT
The role of adenosine receptors in fascial manipulation-induced analgesia has not yet been investigated. The purpose of this study was to evaluate the involvement of the adenosine A1 receptor (A1R) in the antihyperalgesic effect of plantar fascia manipulation (PFM), specifically in mice with peripheral inflammation. Mice injected with Complete Freund's Adjuvant (CFA) underwent behavioral, i.e. mechanical hyperalgesia and edema. The mice underwent PFM for either 3, 9 or 15 min. Response frequency to mechanical stimuli was then assessed at 24 and 96 h after plantar CFA injection. The adenosinergic receptors were assessed by systemic (intraperitoneal, i.p.), central (intrathecal, i.t.), and peripheral (intraplantar, i.pl.) administration of caffeine. The participation of the A1R was investigated using the 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a selective A1R subtype antagonist. PFM inhibited mechanical hyperalgesia induced by CFA injection and did not reduce paw edema. Furthermore, the antihyperalgesic effect of PFM was prevented by pretreatment of the animals with caffeine given by i.p., i.pl., and i.t. routes. In addition, i.pl. and i.t. administrations of DPCPX blocked the antihyperalgesia caused by PFM. These observations indicate that adenosine receptors mediate the antihyperalgesic effect of PFM. Caffeine's inhibition of PFM-induced antihyperalgesia suggests that a more precise understanding of how fascia-manipulation and caffeine interact is warranted.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Xantinas / Adjuvante de Freund / Receptor A1 de Adenosina / Modelos Animais de Doenças / Hiperalgesia / Inflamação Limite: Animals Idioma: En Revista: Neuroscience Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Xantinas / Adjuvante de Freund / Receptor A1 de Adenosina / Modelos Animais de Doenças / Hiperalgesia / Inflamação Limite: Animals Idioma: En Revista: Neuroscience Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos