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Mammaliicoccus sciuri's Pan-Immune System and the Dynamics of Horizontal Gene Transfer Among Staphylococcaceae: a One-Health CRISPR Tale.
de Carvalho, Allan; Giambiagi-deMarval, Marcia; Rossi, Ciro César.
Afiliação
  • de Carvalho A; Department of Biochemistry and Molecular Biology, Federal University of Vicosa, Minas Gerais, 36570-000, Brazil.
  • Giambiagi-deMarval M; Paulo de Góes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
  • Rossi CC; Department of Biochemistry and Molecular Biology, Federal University of Vicosa, Minas Gerais, 36570-000, Brazil. ciro.rossi@ufv.br.
J Microbiol ; 62(9): 775-784, 2024 Sep.
Article em En | MEDLINE | ID: mdl-39037483
ABSTRACT
Recently emancipated from the Staphylococcus genus due to genomic differences, Mammaliicoccus sciuri, previously classified as an occasional pathogen, emerges as a significant player in the landscape of resistance gene dissemination among Staphylococcaceae. Despite its classification, its role remained enigmatic. In this study, we delved into the genomic repertoire of M. sciuri to unravel its contribution to resistance and virulence gene transfer in the context of One Health. Through comprehensive analysis of publicly available genomes, we unveiled a diverse pan-immune system adept at defending against exogenous genetic elements, yet concurrently fostering horizontal gene transfer (HGT). Specifically, exploration of CRISPR-Cas systems, with spacer sequences as molecular signatures, elucidated a global dissemination pattern spanning environmental, animal, and human hosts. Notably, we identified the integration of CRISPR-Cas systems within SCCmecs (Staphylococcal Cassette Chromosome mec), harboring key genes associated with pathogenicity and resistance, especially the methicillin resistance gene mecA, suggesting a strategic adaptation to outcompete other mobile genetic elements. Our findings underscored M. sciuri's active engagement in HGT dynamics and evolutionary trajectories within Staphylococcaceae, emphasizing its central role in shaping microbial communities and highlighting the significance of understanding its implications in the One Health framework, an interdisciplinary approach that recognizes the interconnectedness of human, animal, and environmental health to address global health challenges.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transferência Genética Horizontal / Sistemas CRISPR-Cas / Saúde Única Limite: Animals / Humans Idioma: En Revista: J Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Coréia do Sul
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transferência Genética Horizontal / Sistemas CRISPR-Cas / Saúde Única Limite: Animals / Humans Idioma: En Revista: J Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Coréia do Sul