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The Nutritional Burden of Cancer: Nutritional Status and Body Composition Differences Between Children with Acute Lymphoblastic Leukemia and their Siblings in Guatemala.
Damasco-Avila, Erika; Ubico, Paulina; Blanco, Jessica; Perez, Marisabel; Farncombe, Troy; Morales, Gerson; Antillon-Klussmann, Federico; Ladas, Elena; Barr, Ronald.
Afiliação
  • Damasco-Avila E; Division of Hematology/Oncology/Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, New York.
  • Ubico P; Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala.
  • Blanco J; Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala.
  • Perez M; International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Farncombe T; Tecniscan, Guatemala City, Guatemala.
  • Morales G; Department of Nuclear Medicine, McMaster University and Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada.
  • Antillon-Klussmann F; Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala.
  • Ladas E; Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala.
  • Barr R; School of Medicine, Francisco Marroquín University, Guatemala.
Nutr Cancer ; 76(10): 994-1000, 2024.
Article em En | MEDLINE | ID: mdl-39033402
ABSTRACT
During treatment, children with acute lymphoblastic leukemia (ALL) gain fat mass and lose skeletal muscle mass. The great majority live in low- and middle-income countries with few studies of their body composition and none addressing the hypothesis that the disease itself contributes to nutritional morbidity. At diagnosis, children with ALL were compared to their siblings on socioeconomic status (SES). Nutritional status was assessed by mid-upper arm circumference (MUAC)-for-age Z scores and body composition by dual energy x-ray absorptiometry (DXA). Median SES scores for the patients (47.5) and their siblings (47.0) were very similar (P = 0.5). MUAC Z scores for patients aged >5 years were lower than for siblings (P < 0.001). On DXA siblings had a higher mean appendicular lean mass index Z score, a surrogate of skeletal muscle mass, than patients (P = 0.019). A logistic model to estimate the odds ratio (OR) of being severely/moderately under-nourished (classified by MUAC Z score) by SES revealed that, compared with siblings (n = 49), children with ALL (n = 60) had a higher probability of being under-nourished (OR 5.25, 95% CI 1.44-25.95, P = 0.02). The results support the hypothesis that children at diagnosis of ALL in Guatemala are more nutritionally depleted than their apparently healthy siblings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Composição Corporal / Absorciometria de Fóton / Estado Nutricional / Irmãos / Leucemia-Linfoma Linfoblástico de Células Precursoras Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: America central / Guatemala Idioma: En Revista: Nutr Cancer Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Composição Corporal / Absorciometria de Fóton / Estado Nutricional / Irmãos / Leucemia-Linfoma Linfoblástico de Células Precursoras Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: America central / Guatemala Idioma: En Revista: Nutr Cancer Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos