Potential mechanisms and targeting strategies of the gut microbiota in antitumor immunity and immunotherapy.
Immun Inflamm Dis
; 12(7): e1263, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-39031507
ABSTRACT
BACKGROUND:
Immunotherapies, notably immune checkpoints inhibitors that target programmed death 1/programmed death ligand 1(PD-1/PD-L1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), had profoundly changed the way advanced and metastatic cancers are treated and dramatically improved overall and progression-free survival.AIMS:
This review article aimed to explore the underlying molecular mechanisms by which the gut microbiota affects antitumor immunity and the efficacy of cancer immunotherapy.METHODS:
We summarized the latest knowledge supporting the associations among the gut microbiota, antitumor immunity, and immunotherapy. Moreover, we disscussed the therapeutic strategy for improving immunotherapy efficacy by modulating gut microbiota in cancer treatment.RESULTS:
The potential molecular mechanisms underlying these associations are explained in terms of four aspects immunomodulation, molecular mimicry, mamps, and microbial metabolites.CONCLUSION:
The gut microbiota significantly impacts antitumor immunity and alters the effectiveness of cancer immunotherapy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microbioma Gastrointestinal
/
Imunoterapia
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immun Inflamm Dis
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Reino Unido