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Pharmacological Elevation of Catecholamine Levels Improves Perceptual Decisions, But Not Metacognitive Insight.
Nuiten, Stijn A; de Gee, Jan Willem; Zantvoord, Jasper B; Fahrenfort, Johannes J; van Gaal, Simon.
Afiliação
  • Nuiten SA; Department of Psychology, University of Amsterdam, Amsterdam, Netherlands stijn.nuiten@gmail.com simonvangaal@gmail.com.
  • de Gee JW; Amsterdam Brain & Cognition, University of Amsterdam, Amsterdam, Netherlands.
  • Zantvoord JB; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
  • Fahrenfort JJ; Amsterdam Brain & Cognition, University of Amsterdam, Amsterdam, Netherlands.
  • van Gaal S; Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
eNeuro ; 11(7)2024 Jul.
Article em En | MEDLINE | ID: mdl-39029953
ABSTRACT
Perceptual decisions are often accompanied by a feeling of decision confidence. Where the parietal cortex is known for its crucial role in shaping such perceptual decisions, metacognitive evaluations are thought to additionally rely on the (pre)frontal cortex. Because of this supposed neural differentiation between these processes, perceptual and metacognitive decisions may be divergently affected by changes in internal (e.g., attention, arousal) and external (e.g., task and environmental demands) factors. Although intriguing, causal evidence for this hypothesis remains scarce. Here, we investigated the causal effect of two neuromodulatory systems on behavioral and neural measures of perceptual and metacognitive decision-making. Specifically, we pharmacologically elevated levels of catecholamines (with atomoxetine) and acetylcholine (with donepezil) in healthy adult human participants performing a visual discrimination task in which we gauged decision confidence, while electroencephalography was measured. Where cholinergic effects were not robust, catecholaminergic enhancement improved perceptual sensitivity, while at the same time leaving metacognitive sensitivity unaffected. Neurally, catecholaminergic elevation did not affect sensory representations of task-relevant visual stimuli but instead enhanced well-known decision signals measured over the centroparietal cortex, reflecting the accumulation of sensory evidence over time. Crucially, catecholaminergic enhancement concurrently impoverished neural markers measured over the frontal cortex linked to the formation of metacognitive evaluations. Enhanced catecholaminergic neuromodulation thus improves perceptual but not metacognitive decision-making.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecolaminas / Tomada de Decisões / Eletroencefalografia / Cloridrato de Atomoxetina / Metacognição Limite: Adult / Female / Humans / Male Idioma: En Revista: ENeuro Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecolaminas / Tomada de Decisões / Eletroencefalografia / Cloridrato de Atomoxetina / Metacognição Limite: Adult / Female / Humans / Male Idioma: En Revista: ENeuro Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos