Your browser doesn't support javascript.
loading
Five centuries of genome evolution and multi-host adaptation of Campylobacter jejuni in Brazil.
Buiatte, Ana Beatriz Garcez; Souza, Stephanie S R; Costa, Leticia Roberta Martins; Peres, Phelipe Augusto Borba Martins; de Melo, Roberta Torres; Sommerfeld, Simone; Fonseca, Belchiolina Beatriz; Zac Soligno, Nicole I; Ikhimiukor, Odion O; Armendaris, Paulo Marcel; Andam, Cheryl P; Rossi, Daise Aparecida.
Afiliação
  • Buiatte ABG; Molecular Epidemiology Laboratory, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Souza SSR; Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA.
  • Costa LRM; Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA.
  • Peres PABM; Molecular Epidemiology Laboratory, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • de Melo RT; Nanobiotechnology Laboratory, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Sommerfeld S; Molecular Epidemiology Laboratory, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Fonseca BB; Infectious Disease Laboratory, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Zac Soligno NI; Infectious Disease Laboratory, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
  • Ikhimiukor OO; Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA.
  • Armendaris PM; Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA.
  • Andam CP; Federal Agriculture Defense Laboratory/RS - LFDA/RS, Porto Alegre, Rio Grande do Sul, Brazil.
  • Rossi DA; Department of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA.
Microb Genom ; 10(7)2024 Jul.
Article em En | MEDLINE | ID: mdl-39028633
ABSTRACT
Consumption of raw, undercooked or contaminated animal food products is a frequent cause of Campylobacter jejuni infection. Brazil is the world's third largest producer and a major exporter of chicken meat, yet population-level genomic investigations of C. jejuni in the country remain scarce. Analysis of 221 C. jejuni genomes from Brazil shows that the overall core and accessory genomic features of C. jejuni are influenced by the identity of the human or animal source. Of the 60 sequence types detected, ST353 is the most prevalent and consists of samples from chicken and human sources. Notably, we identified the presence of diverse bla genes from the OXA-61 and OXA-184 families that confer beta-lactam resistance as well as the operon cmeABCR related to multidrug efflux pump, which contributes to resistance against tetracyclines, macrolides and quinolones. Based on limited data, we estimated the most recent common ancestor of ST353 to the late 1500s, coinciding with the time the Portuguese first arrived in Brazil and introduced domesticated chickens into the country. We identified at least two instances of ancestral chicken-to-human infections in ST353. The evolution of C. jejuni in Brazil was driven by the confluence of clinically relevant genetic elements, multi-host adaptation and clonal population growth that coincided with major socio-economic changes in poultry farming.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Galinhas / Campylobacter jejuni / Genoma Bacteriano / Evolução Molecular Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Microb Genom Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Galinhas / Campylobacter jejuni / Genoma Bacteriano / Evolução Molecular Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Microb Genom Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido