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The profile of blood microbiome in new-onset type 1 diabetes children.
Yuan, Xiaoxiao; Yang, Xin; Xu, Zhenran; Li, Jie; Sun, ChengJun; Chen, Ruimin; Wei, Haiyan; Chen, Linqi; Du, Hongwei; Li, Guimei; Yang, Yu; Chen, Xiaojuan; Cui, Lanwei; Fu, Junfen; Wu, Jin; Chen, Zhihong; Fang, Xin; Su, Zhe; Zhang, Miaoying; Wu, Jing; Chen, Xin; Zhou, Jiawei; Luo, Yue; Zhang, Lei; Wang, Ruirui; Luo, Feihong.
Afiliação
  • Yuan X; Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
  • Yang X; Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
  • Xu Z; Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
  • Li J; Section of Endocrinology, Internal Medicine, School of Medicine, Yale University, New Haven, CT 06511, United States.
  • Sun C; Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
  • Chen R; Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
  • Wei H; Teaching and Research Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong 999077, China.
  • Chen L; Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
  • Du H; Fuzhou Children's Hospital of Fujian Medical University, Fuzhou 350000, China.
  • Li G; Department of Endocrinology and Inherited Metabolic, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450000, China.
  • Yang Y; Children's Hospital of Soochow University, Suzhou 215000, China.
  • Chen X; The First Hospital of Jilin University, Jilin 130000, China.
  • Cui L; Department of Pediatric Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.
  • Fu J; The Affiliated Children's Hospital of Nanchang University, Nanchang 330006, China.
  • Wu J; Department of Endocrinology, Genetics and Metabolism, The Children's Hospital of Shanxi Province, Taiyuan 030013, China.
  • Chen Z; The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
  • Fang X; Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310005, China.
  • Su Z; Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
  • Zhang M; Department of Neuroendocrinology Pediatrics, Affiliated Hospital of Qingdao University, Qingdao 266003, China.
  • Wu J; Fujian Medical University Union Hospital, Fuzhou 350001, China.
  • Chen X; Shenzhen Children's Hospital, Shenzhen 518038, China.
  • Zhou J; Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
  • Luo Y; Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
  • Zhang L; Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
  • Wang R; Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
  • Luo F; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
iScience ; 27(7): 110252, 2024 Jul 19.
Article em En | MEDLINE | ID: mdl-39027370
ABSTRACT
Blood microbiome signatures in patients with type 1 diabetes (T1D) remain unclear. We profile blood microbiome using 16S rRNA gene sequencing in 77 controls and 64 children with new-onset T1D, and compared it with the gut and oral microbiomes. The blood microbiome of patients with T1D is characterized by increased diversity and perturbed microbial features, with a significant increase in potentially pathogenic bacteria compared with controls. Thirty-six representative genera of blood microbiome were identified by random forest analysis, providing strong discriminatory power for T1D with an AUC of 0.82. PICRUSt analysis suggested that bacteria capable of inducing inflammation were more likely to enter the bloodstream in T1D. The overlap of the gut and oral microbiome with the blood microbiome implied potential translocation of bacteria from the gut and oral cavity to the bloodstream. Our study raised the necessity of further mechanistic investigations into the roles of blood microbiome in T1D.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos