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Zinc-Modified Titanate Nanotubes as Radiosensitizers for Glioblastoma: Enhancing Radiotherapy Efficacy and Monte Carlo Simulations.
Diz, Fernando Mendonça; Monteiro, Wesley F; Silveira, Iury Santos; Ruano, Daniel; Zotti, Eduardo Rosa; Weimer, Rafael Diogo; Melo, Micael Nunes; Schossler Lopes, João Gabriel; Scheffel, Thamiris Becker; Caldas, Linda V E; da Costa, Jaderson Costa; Morrone, Fernanda Bueno; Ligabue, Rosane Angélica.
Afiliação
  • Diz FM; Preclinical Research Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.
  • Monteiro WF; Graduate Program in Materials Engineering and Technology, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.
  • Silveira IS; Graduate Program in Materials Engineering and Technology, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.
  • Ruano D; Institute of Energy and Nuclear Research, National Nuclear Energy Commission-IPEN/CNEN. São Paulo, São Paulo 01151, Brazil.
  • Zotti ER; ALBA Syconhrotron Light Source, Cerdanuola del Vallès 08290, Spain.
  • Weimer RD; Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científica (UPV-CSIC), Valencia 46022, Spain.
  • Melo MN; Graduate Program in Materials Engineering and Technology, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.
  • Schossler Lopes JG; Graduate Program in Materials Engineering and Technology, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.
  • Scheffel TB; Institute of Technology and Research-ITP, Aracaju, Sergipe 49032-490 Brazil.
  • Caldas LVE; Radiotherapy Service at Hospital São Lucas da Pontifical Catholic University of Rio Grande do Sul/Oncoclinic Group, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.
  • da Costa JC; Preclinical Research Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.
  • Morrone FB; Institute of Energy and Nuclear Research, National Nuclear Energy Commission-IPEN/CNEN. São Paulo, São Paulo 01151, Brazil.
  • Ligabue RA; Preclinical Research Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.
ACS Omega ; 9(27): 29499-29515, 2024 Jul 09.
Article em En | MEDLINE | ID: mdl-39005768
ABSTRACT
Radiotherapy (RT) is the established noninvasive treatment for glioblastoma (GBM), a highly aggressive malignancy. However, its effectiveness in improving patient survival remains limited due to the radioresistant nature of GBM. Metal-based nanostructures have emerged as promising strategies to enhance RT efficacy. Among them, titanate nanotubes (TNTs) have gained significant attention due to their biocompatibility and cost-effectiveness. This study aimed to synthesize zinc-modified TNTs (ZnTNT) from sodium TNTs (NaTNT), in addition to characterizing the formed nanostructures and evaluating their radiosensitization effects in GBM cells (U87 and U251). Hydrothermal synthesis was employed to fabricate the TNTs, which were characterized using various techniques, including transmission electron microscopy (TEM), energy-dispersive spectroscopy, scanning-transmission mode, Fourier-transform infrared spectroscopy, ICP-MS (inductively coupled plasma mass spectrometry), X-ray photoelectron spectroscopy, and zeta potential analysis. Cytotoxicity was evaluated in healthy (Vero) and GBM (U87 and U251) cells by the MTT assay, while the internalization of TNTs was observed through TEM imaging and ICP-MS. The radiosensitivity of ZnTNT and NaTNT combined with 5 Gy was evaluated using clonogenic assays. Monte Carlo simulations using the MCNP6.2 code were performed to determine the deposited dose in the culture medium for RT scenarios involving TNT clusters and cells. The results demonstrated differences in the dose deposition values between the scenarios with and without TNTs. The study revealed that ZnTNT interfered with clonogenic integrity, suggesting its potential as a powerful tool for GBM treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos