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Effectiveness of pharmacological interventions for managing ADHD symptoms in individuals with autism spectrum disorder: A systematic review and meta-analysis.
Martins, Paulo Levi Bezerra; Torquato, Gustavo César Parente; Dias, Gabriel Alberto Pinheiro Fernandes; Leite, Isabel Bessa; Gaspar, Thays Macedo; Pinto, Joel Porfírio; Macedo, Danielle S.
Afiliação
  • Martins PLB; Public Health School Visconde de Saboia, Sobral, CE, Brazil.
  • Torquato GCP; Health Sciences Center, Fortaleza University (UNIFOR), Fortaleza, CE, Brazil.
  • Dias GAPF; Department of Physiology and Pharmacology, Faculty of Medicine, Neuropsychopharmacology and Translational Psychiatry Laboratory, Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
  • Leite IB; Department of Physiology and Pharmacology, Faculty of Medicine, Neuropsychopharmacology and Translational Psychiatry Laboratory, Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
  • Gaspar TM; Health Sciences Center, Fortaleza University (UNIFOR), Fortaleza, CE, Brazil.
  • Pinto JP; Health Sciences Center, Fortaleza University (UNIFOR), Fortaleza, CE, Brazil.
  • Macedo DS; Department of Physiology and Pharmacology, Faculty of Medicine, Neuropsychopharmacology and Translational Psychiatry Laboratory, Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil. Electronic address: danielle.macedo@ufc.br.
Prog Neuropsychopharmacol Biol Psychiatry ; 134: 111089, 2024 Aug 30.
Article em En | MEDLINE | ID: mdl-39004333
ABSTRACT

OBJECTIVES:

This systematic review sought to provide evidence for the effectiveness of common pharmacological interventions used for treating attention deficit hyperactivity disorder (ADHD) symptoms in the autism spectrum disorder (ASD) population, considering studies attempting to find safe and effective drugs.

METHODS:

We searched for randomized controlled trials describing the effectiveness and/or safety profile of pharmacological interventions for treating ASD and ADHD or ASD with ADHD symptoms using three bibliographic databases PubMed, Cochrane Library, and Embase. We have chosen ADHD symptoms measured by any clinical scale as the primary outcome. As additional outcomes, we have used other symptoms of aberrant behavior measured by the aberrant behavior checklist, satisfaction with treatment, and peer satisfaction.

RESULTS:

Twenty-two publications met the inclusion criteria for the systematic review and eight for the meta-analysis. In our investigation, we found a few articles using clonidine, modafinil, and bupropion as interventions when compared to methylphenidate (MPH). Our meta-analysis showed that MPH had positive changes compared to placebo in symptoms such as hyperactivity, irritability, or inattention. However, no effect was found in stereotyped symptoms, and our data's quantitative analysis revealed a large effect of MPH-induced adverse effects on the dropout rate. On the other hand, atomoxetine initiation had positive effects when compared to placebo on symptoms of hyperactivity and inattention. We have found no effect of atomoxetine on stereotypes or irritability. Furthermore, atomoxetine did not influence side effects that caused dropouts from studies.

CONCLUSION:

Our results indicated that atomoxetine has a modest effect on hyperactivity and inattention symptoms, with a relatively benign profile of side effects. MPH appears to be effective in handling hyperactivity, inattention, and irritability symptoms. However, our results on atomoxetine revealed increased dropouts due to adverse effects when compared to MPH or placebo. Evidence for other substances such as guanfacine, clonidine, bupropion, or modafinil is either preliminary or nonexistent.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Transtorno do Espectro Autista Limite: Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Transtorno do Espectro Autista Limite: Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido