Predominance of CD137<sup>+</sup> And TNF-&#945; Expressing CD8<sup>+</sup> Central Memory T Cells in Mild COVID-19 Recovered Patients Upon SARS-CoV-2 Re-Exposure.

Peixoto, Rephany Fonseca; de Sousa Palmeira, Pedro Henrique; Csordas, Bárbara Guimarães; Cavalcante-Silva, Luiz Henrique Agra; de Andrade, Arthur Gomes; de Medeiros, Isac Almeida; de Lourdes Assunção Araújo de Azevedo, Fátima; Veras, Robson Cavalcante; Janebro, Daniele; Do Amaral, Ian P G; Keesen, Tatjana Souza Lima

Predominance of CD137⁺ And TNF-α Expressing CD8⁺ Central Memory T Cells in Mild COVID-19 Recovered Patients Upon SARS-CoV-2 Re-Exposure.

Peixoto, Rephany Fonseca; de Sousa Palmeira, Pedro Henrique; Csordas, Bárbara Guimarães; Cavalcante-Silva, Luiz Henrique Agra; de Andrade, Arthur Gomes; de Medeiros, Isac Almeida; de Lourdes Assunção Araújo de Azevedo, Fátima; Veras, Robson Cavalcante; Janebro, Daniele; Do Amaral, Ian P G; Keesen, Tatjana Souza Lima.

Afiliação

Peixoto RF; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.
de Sousa Palmeira PH; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.
Csordas BG; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.
Cavalcante-Silva LHA; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.
de Andrade AG; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.
de Medeiros IA; Department of Pharmaceutical Sciences, Health Science Center, João Pessoa, Brazil.
de Lourdes Assunção Araújo de Azevedo F; Department of Pharmaceutical Sciences, Health Science Center, João Pessoa, Brazil.
Veras RC; Department of Pharmaceutical Sciences, Health Science Center, João Pessoa, Brazil.
Janebro D; Department of Pharmaceutical Sciences, Health Science Center, João Pessoa, Brazil.
Do Amaral IPG; Biotechnology Graduation Program, Federal University of Paraiba, João Pessoa, Brazil.
Keesen TSL; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.

Immunol Invest ; 53(7): 1092-1101, 2024 Oct.

Article em En | MEDLINE | ID: mdl-38994913

ABSTRACT

ABSTRACT

INTRODUCTION:

Memory CD8+ T cells are essential for long-term immune protection in viral infections, including COVID-19.

METHODS:

This study examined the responses of CD8+ TEM, TEMRA, and TCM subsets from unvaccinated individuals who had recovered from mild and severe COVID-19 by flow cytometry. RESULTS AND

DISCUSSION:

The peptides triggered a higher frequency of CD8+ TCM cells in the recovered mild group. CD8+ TCM and TEM cells showed heterogeneity in CD137 expression between evaluated groups. In addition, a predominance of CD137 expression in naïve CD8+ T cells, TCM, and TEM was observed in the mild recovered group when stimulated with peptides. Furthermore, CD8+ TCM and TEM cell subsets from mild recovered volunteers had higher TNF-α expression. In contrast, the expression partner of IFN-Î³, IL-10, and IL-17 indicated an antiviral signature by CD8+ TEMRA cells. These findings underscore the distinct functional capabilities of each memory T cell subset in individuals who have recovered from COVID-19 upon re-exposure to SARS-CoV-2 antigens.

Assuntos

Linfócitos T CD8-Positivos; COVID-19; Células T de Memória; SARS-CoV-2; Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral; Fator de Necrose Tumoral alfa; Humanos; COVID-19/imunologia; Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/metabolismo; Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/imunologia; SARS-CoV-2/imunologia; Linfócitos T CD8-Positivos/imunologia; Fator de Necrose Tumoral alfa/metabolismo; Células T de Memória/imunologia; Masculino; Adulto; Pessoa de Meia-Idade; Feminino; Memória Imunológica/imunologia

Palavras-chave

COVID-19; Central memory T cells; Immunological memory; SARS-CoV-2 infection; effector memory T cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Linfócitos T CD8-Positivos / Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral / SARS-CoV-2 / COVID-19 / Células T de Memória Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Immunol Invest Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

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