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1,25-Dihydroxyvitamin D3 reduces early mortality post severe burn injury via alleviating endotoxemia, oxidative stress and inflammation.
Chen, Yu; Guo, Jing Hui; Chen, Ya Jie; Huang, Yong; Zhang, Cheng; Zhang, Qiong; Gong, Ya Li; Chen, Jing.
Afiliação
  • Chen Y; State Key Laboratory of Trauma and Chemical Poisoning of China, Institute of Burn Research, Southwest Hospital (the First Affiliated Hospital), Third Military Medical University, (Army Medical University), Gao Tan Yan Street, Chongqing 400038, China.
  • Guo JH; School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.
  • Chen YJ; State Key Laboratory of Trauma and Chemical Poisoning of China, Institute of Burn Research, Southwest Hospital (the First Affiliated Hospital), Third Military Medical University, (Army Medical University), Gao Tan Yan Street, Chongqing 400038, China.
  • Huang Y; State Key Laboratory of Trauma and Chemical Poisoning of China, Institute of Burn Research, Southwest Hospital (the First Affiliated Hospital), Third Military Medical University, (Army Medical University), Gao Tan Yan Street, Chongqing 400038, China.
  • Zhang C; State Key Laboratory of Trauma and Chemical Poisoning of China, Institute of Burn Research, Southwest Hospital (the First Affiliated Hospital), Third Military Medical University, (Army Medical University), Gao Tan Yan Street, Chongqing 400038, China.
  • Zhang Q; State Key Laboratory of Trauma and Chemical Poisoning of China, Institute of Burn Research, Southwest Hospital (the First Affiliated Hospital), Third Military Medical University, (Army Medical University), Gao Tan Yan Street, Chongqing 400038, China.
  • Gong YL; State Key Laboratory of Trauma and Chemical Poisoning of China, Institute of Burn Research, Southwest Hospital (the First Affiliated Hospital), Third Military Medical University, (Army Medical University), Gao Tan Yan Street, Chongqing 400038, China.
  • Chen J; State Key Laboratory of Trauma and Chemical Poisoning of China, Institute of Burn Research, Southwest Hospital (the First Affiliated Hospital), Third Military Medical University, (Army Medical University), Gao Tan Yan Street, Chongqing 400038, China. Electronic address: chenjingtmmu@Tmmu.edu.cn.
Burns ; 50(7): 1790-1798, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38987082
ABSTRACT
Severe burn patients frequently suffer from 1,25-Dihydroxyvitamin D3 (1,25-[OH]2-D3) deficiency. In this study, we investigated the effect of 1,25-[OH]2-D3 on early mortality post severe burn and potential underlying mechanisms. Our results indicate that 1,25-[OH]2-D3 significantly reduced early mortality in mice post severe burn injury. A decrease in serum lipopolysaccharide levels and an increase in serum superoxide dismutase activity were found after administration of 1,25-[OH]2-D3. Furthermore, 1,25-[OH]2-D3 demonstrated protective effects on both intestinal and lung histology and ameliorated lung inflammation. Its anti-inflammatory effect was further confirmed in airway epithelial cells. In conclusion, our study provides evidence that 1,25-[OH]2-D3 has a significant impact on the reduction of early mortality post severe burn injury, possibly through its ability to alleviate endotoxemia, oxidative stress, and inflammation. Our findings highlight the potential of 1,25-[OH]2-D3 to protect the intestinal mucosal barrier in the early stage following major burn injury and opens up new avenues for clinical application of 1,25-[OH]2-D3 in burn patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Queimaduras / Estresse Oxidativo / Endotoxemia / Inflamação / Mucosa Intestinal Limite: Animals Idioma: En Revista: Burns Assunto da revista: TRAUMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Queimaduras / Estresse Oxidativo / Endotoxemia / Inflamação / Mucosa Intestinal Limite: Animals Idioma: En Revista: Burns Assunto da revista: TRAUMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Holanda