Fipronil and (S)-methoprene can lessen the risk of transmission of Bartonella clarridgeiae among cats with exposure to Ctenocephalides felis.

Peralta, Jade A; Carithers, Douglas S; Beugnet, Frederik; Lappin, Michael R

Peralta, Jade A; Carithers, Douglas S; Beugnet, Frederik; Lappin, Michael R.

Afiliação

Peralta JA; Department of Clinical Sciences, Colorado State University, Fort Collins, CO.
Carithers DS; Boehringer Ingelheim, Duluth, GA.
Beugnet F; Boehringer Ingelheim, Lyon, France.
Lappin MR; Department of Clinical Sciences, Colorado State University, Fort Collins, CO.

Am J Vet Res ; 85(9)2024 Sep 01.

Article em En | MEDLINE | ID: mdl-38984890

ABSTRACT

ABSTRACT

OBJECTIVE:

To cohouse cats experimentally infected with Bartonella clarridgeiae (Bc) with naive cats in a flea-free environment or with Ctenocephalides felis, Bartonella henselae (Bh), Mycoplasma haemofelis, and Candidatus Mycoplasma haemominutum to determine which flea could be a vector and to assess whether transmission of the infectious agents could be blocked by fipronil and (S)-methoprene. ANIMALS Specific pathogen-free cats (n = 34).

METHODS:

In experiment 1, Bc was inoculated in 1 cat that was housed with 9 naive cats without C felis. In experiment 2, the 2 cats inoculated with Bc were housed with 6 other cats (2 inoculated with Bh, 2 inoculated with M haemofelis, and 2 inoculated with Candidatus M haemominutum) in the center (enclosure 2) of 3 housing enclosures separated by mesh walls that allow passage of fleas but precludes fighting. C felis were placed only on cats in enclosure 2 (5 times). Cats in enclosures 1 (n = 8) and 2 (8) were untreated, and cats in enclosure 3 (8) were administered fipronil and (S)-methoprene. Blood was collected from all cats for PCR assays for the pathogens.

RESULTS:

None of the cats housed with the cat inoculated with Bc became PCR positive in the absence of C felis. All cats in enclosure 2 became Bc DNA positive. While 2 of 8 cats in enclosure 1 became Bc PCR positive, none of the treated cats in enclosure 3 became infected. CLINICAL RELEVANCE The study demonstrated that C felis can be a vector for Bc. The results support the recommendation that flea control products can reduce the risk of transmission of flea-borne pathogens.

Assuntos

Infecções por Bartonella; Bartonella; Doenças do Gato; Ctenocephalides; Metoprene; Pirazóis; Animais; Gatos; Doenças do Gato/transmissão; Doenças do Gato/microbiologia; Doenças do Gato/prevenção & controle; Ctenocephalides/microbiologia; Ctenocephalides/efeitos dos fármacos; Pirazóis/farmacologia; Metoprene/farmacologia; Infecções por Bartonella/transmissão; Infecções por Bartonella/veterinária; Infecções por Bartonella/prevenção & controle; Infestações por Pulgas/veterinária; Infestações por Pulgas/transmissão; Infestações por Pulgas/prevenção & controle; Inseticidas/farmacologia; Feminino; Masculino; Organismos Livres de Patógenos Específicos; Mycoplasma; Insetos Vetores/microbiologia

Palavras-chave

Bartonella clarridgeiae; Ctenocephalides felis; fipronil and (S)-methoprene; transmission; vector

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Bartonella / Infecções por Bartonella / Doenças do Gato / Ctenocephalides / Metoprene Limite: Animals Idioma: En Revista: Am J Vet Res Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos

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