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Blood-Brain Barrier Permeability Is Associated With Cognitive Functioning in Normal Aging and Neurodegenerative Diseases.
Hergert, Danielle C; Gaasedelen, Owen; Ryman, Sephira G; Prestopnik, Jillian; Caprihan, Arvind; Rosenberg, Gary A.
Afiliação
  • Hergert DC; US Department of Energy (Contractor), Kirtland Air Force Base Albuquerque NM USA.
  • Gaasedelen O; Independent Practice Albuquerque NM USA.
  • Ryman SG; The Mind Research Network/Lovelace Biomedical Research Institute Albuquerque NM USA.
  • Prestopnik J; Department of Neurology University of New Mexico Health Sciences Center Albuquerque NM USA.
  • Caprihan A; Center for Memory & Aging University of New Mexico Health Sciences Center Albuquerque NM USA.
  • Rosenberg GA; The Mind Research Network/Lovelace Biomedical Research Institute Albuquerque NM USA.
J Am Heart Assoc ; 13(14): e034225, 2024 Jul 16.
Article em En | MEDLINE | ID: mdl-38979810
ABSTRACT

BACKGROUND:

The purpose of this study was to investigate the relationship between blood-brain barrier (BBB) permeability and cognitive functioning in healthy older adults and individuals with neurodegenerative diseases. METHODS AND

RESULTS:

A total of 124 participants with Alzheimer disease, cerebrovascular disease, or a mix Alzheimer's and cerebrovascular diseases and 55 controlparticipants underwent magnetic resonance imaging and neuropsychological testing. BBB permeability was measured with dynamic contrast-enhanced magnetic resonance imaging and white matter injury was measured using a quantitative diffusion-tensor imaging marker of white matter injury. Structural equation modeling was used to examine the relationships between BBB permeability, vascular risk burden, white matter injury, and cognitive functioning. Vascular risk burden predicted BBB permeability (r=0.24, P<0.05) and white matter injury (r=0.38, P<0.001). BBB permeability predicted increased white matter injury (r=0.34, P<0.001) and increased white matter injury predicted lower cognitive functioning (r=-0.51, P<0.001).

CONCLUSIONS:

The study provides empirical support for a vascular contribution to white matter injury and cognitive impairment, directly or indirectly via BBB permeability. This highlights the importance of targeting modifiable vascular risk factors to help mitigate future cognitive decline.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Cognição Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Cognição Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido