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Infection by zika virus increase angiotensin I-converting enzyme activity in mouse brain.
Oyadomari, William Y; Christoff, Raissa R; Nani, João V; Rabello, Tailene; Oliveira, Vitor; Higa, Luiza M; Garcez, Patrícia P; Hayashi, Mirian A F.
Afiliação
  • Oyadomari WY; Department of Pharmacology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), SP, Brazil.
  • Christoff RR; Instituto de Ciências Biomédicas, Universidade Federal Do Rio de Janeiro (UFRJ), RJ, Brazil.
  • Nani JV; Department of Pharmacology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), SP, Brazil.
  • Rabello T; Instituto de Ciências Biomédicas, Universidade Federal Do Rio de Janeiro (UFRJ), RJ, Brazil.
  • Oliveira V; Department of Biophysics, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), SP, Brazil.
  • Higa LM; Instituto de Biologia, Universidade Federal Do Rio de Janeiro (UFRJ), RJ, Brazil.
  • Garcez PP; Instituto de Ciências Biomédicas, Universidade Federal Do Rio de Janeiro (UFRJ), RJ, Brazil.
  • Hayashi MAF; Department of Pharmacology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), SP, Brazil. Electronic address: mhayashi@unifesp.br.
Biochimie ; 2024 Jul 02.
Article em En | MEDLINE | ID: mdl-38960371
ABSTRACT
Congenital zika virus syndrome (CZS) has become a significant worldwide concern since the sudden rise of microcephaly related to zika virus (ZIKV) in Brazil. Primarily transmitted by Aedes mosquitoes, ZIKV shares serologic similarities with dengue virus (DENV), complicating the diagnosis and/or clinical management. The Angiotensin I-Converting Enzyme (ACE) was associated with either neuroprotective or anti-inflammatory properties in the central nervous system (CNS). The possible role(s) of ACE in these two flaviviruses infection remain largely unexplored. In this study, we evaluate ACE activity in the brain of ZIKV- or DENV-infected mice, both compared to MOCK, showing about 30 % increased ACE activity only in ZIKV-infected mice (p = 0.024), while no change was noticed in brain from DENV-infected animals (p = 0.888). In addition, the treatment with interferon beta (IFNß), under conditions previously demonstrated to rescue the normal size of microcephalic brains determined by ZIKV infection, also restored ACE activity in ZIKV-infected animals to levels close to that of the MOCK control group. Although inflammatory responses expected for either ZIKV or DENV infections, only ZIKV was associated with microcephaly, as well as with increased ACE activity and reversion by treatment with IFNß. Furthermore, this increase in ACE activity was observed only after intracerebroventricular (ICV) injection (F (2, 16) = 7.907, p = 0.004), but not for intraperitoneal (IP) administration of ZIKV (F (2, 26) = 1.996, p = 0.156), suggesting that the observed central ACE activity modulation may be associated with the presence of this specific flavivirus in the brain.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biochimie Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biochimie Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: França