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Nutriomic Effects of Precision Lipids on Murine Hepatic Triacylglycerol Alterations Induced by High-Fat Diets.
Fariña, Ana Clara; Lavandera, Jimena Verónica; Candioti, Luciana Vera; Suppo, Candela Luján; Bernal, Claudio Adrián.
Afiliação
  • Fariña AC; Cátedra de Bromatología y Nutrición, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
  • Lavandera JV; Cátedra de Bromatología y Nutrición, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
  • Candioti LV; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina.
  • Suppo CL; Cátedra de Bromatología y Nutrición, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
  • Bernal CA; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina.
Lifestyle Genom ; 17(1): 82-92, 2024.
Article em En | MEDLINE | ID: mdl-38952113
ABSTRACT

INTRODUCTION:

This study aims to investigate if a mixture of functional lipids (FLs), containing conjugated linoleic acid (CLA), tocopherols (TPs), and phytosterols (PSs), prevents some lipid alterations induced by high-fat (HF) diets, without adverse effects.

METHODS:

Male CF1 mice (n = 6/group) were fed (4 weeks) with control (C), HF, or HF + FL diets.

RESULTS:

FL prevented the overweight induced by the HF diet and reduced the adipose tissue (AT) weight, associated with lower energy efficiency. After the intervention period, the serum triacylglycerol (TAG) levels in both HF diets underwent a decrease associated with an enhanced LPL activity (mainly in muscle). The beneficial effect of the FL mixture on body weight gain and AT weight might be attributed to the decreased lipogenesis, denoted by the lower mRNA levels of SREBP1-c and ACC in AT, as well as by an exacerbated lipid catabolism, reflected by increased mRNA levels of PPARα, ATGL, HSL, and UCP2 in AT. Liver TAG levels were reduced in the HF + FL group due to an elevated lipid oxidation associated with a higher CPT-1 activity and mRNA levels of PPARα and CPT-1a. Moreover, genes linked to fatty acid biosynthesis (SREBP1-c and ACC) showed decreased mRNA levels in both HF diets, this finding being more pronounced in the HF + FL group.

CONCLUSION:

The administration of an FL mixture (CLA + TP + PS) prevented some lipid alterations induced by a HF diet, avoiding frequent deleterious effects of CLA in mice through the modulation of gene expression related to the regulation of lipid metabolism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Ácidos Linoleicos Conjugados / PPAR alfa / Proteína de Ligação a Elemento Regulador de Esterol 1 / Metabolismo dos Lipídeos / Dieta Hiperlipídica / Fígado Limite: Animals Idioma: En Revista: Lifestyle Genom Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Ácidos Linoleicos Conjugados / PPAR alfa / Proteína de Ligação a Elemento Regulador de Esterol 1 / Metabolismo dos Lipídeos / Dieta Hiperlipídica / Fígado Limite: Animals Idioma: En Revista: Lifestyle Genom Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça