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Usefulness of vancomycin treatment individualization via Bayesian algorithms: a 5-year study in critical patients.
Figueroa, Salvador Cabrera; Pincheira, Diego Salazar; Navarrete, Claudio Bustos; Panés, Juan Hermosilla; Montecinos, Sergio Mella; Cabrera, Leonila Ferreira.
Afiliação
  • Figueroa SC; Personalized Therapy Unit, Regional Clinical Dr. Guillermo Grant Benavente Hospital, San Martín 1436, Concepción, Chile.
  • Pincheira DS; Pharmacy Department, Pharmacy Faculty, University of Concepcion, Víctor Lamas 1290, Concepción, Chile.
  • Navarrete CB; Personalized Therapy Unit, Regional Clinical Dr. Guillermo Grant Benavente Hospital, San Martín 1436, Concepción, Chile.
  • Panés JH; Pharmacy Department, Pharmacy Faculty, University of Concepcion, Víctor Lamas 1290, Concepción, Chile.
  • Montecinos SM; Psychology Department, Faculty of Social Sciences, University of Concepcion, Víctor Lamas 1290, Concepción, Chile.
  • Cabrera LF; Department of Internal Medicine, Medicine Faculty & Science, San Sebastian University, Lientur 1457, Concepción, Chile.
Per Med ; 21(4): 243-255, 2024.
Article em En | MEDLINE | ID: mdl-38940364
ABSTRACT

Aim:

Compare two vancomycin dosing strategies in critical patients with methicillin-resistant Staphylococcus aureus (MRSA) infections, considering the heterogeneity of the dosing regimens administered and their implications for toxicity and efficacy. Materials &

methods:

Longitudinal retrospective observational study in two patient cohorts (standard dosing vs dosing via Bayesian algorithms).

Results:

The group of Bayesian algorithms received substantially higher and significantly heterogeneous doses, with an absence of nephrotoxicity. The speed of decrease observed in CRP and PCT was greater for the Bayesian strategy (p = 0.045 and 0.0009, respectively).

Conclusion:

Applying Bayesian algorithms to vancomycin dosage individualization allows for administering much higher doses than with standard regimens, facilitating a quicker clinical response in the absence of nephrotoxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Algoritmos / Vancomicina / Teorema de Bayes / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Per Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Algoritmos / Vancomicina / Teorema de Bayes / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Per Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido