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Unveiling contrasts in microbiota response: A1c control improves dysbiosis in low-A1c T2DM, but fails in high-A1c cases-a key to metabolic memory?
Napoli, Thiago Fraga; Cortez, Ramon V; Sparvoli, Luiz Gustavo; Taddei, Carla R; Salles, Joao Eduardo Nunes.
Afiliação
  • Napoli TF; Serviço de Endocrinologia e Metabologia, Hospital Servidor Público Estadual de São Paulo, São Paulo, São Paulo, Brazil napoli38@gmail.com.
  • Cortez RV; Departamento de Clínica Médica, Disciplina de Endocrinologia, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.
  • Sparvoli LG; Department of Clinical Analysis and Toxicology, University of Sao Paulo, Sao Paulo, Brazil.
  • Taddei CR; Department of Clinical Analysis and Toxicology, University of Sao Paulo, Sao Paulo, Brazil.
  • Salles JEN; Department of Clinical Analysis and Toxicology, University of Sao Paulo, Sao Paulo, Brazil.
BMJ Open Diabetes Res Care ; 12(3)2024 Jun 27.
Article em En | MEDLINE | ID: mdl-38937275
ABSTRACT

INTRODUCTION:

Type 2 diabetes mellitus (T2DM) is associated with dysbiosis in the gut microbiota (MB). Individually, each medication appears to partially correct this. However, there are no studies on the response of the MB to changes in A1c. Therefore, we investigated the MB's response to intensive glycemic control. RESEARCH DESIGN AND

METHODS:

We studied two groups of patients with uncontrolled T2DM, one group with an A1c <9% (18 patients-G1) and another group with an A1c >9% (13 patients-G2), aiming for at least a 1% reduction in A1c. We collected A1c and fecal samples at baseline, 6, and 12 months. G1 achieved an average A1c reduction of 1.1%, while G2 a reduction of 3.13%.

RESULTS:

G1's microbiota saw a decrease in Erysipelotrichaceae_UCG_003 and in Mollicutes order (both linked to metabolic syndrome and associated comorbidities). G2, despite having a more significant reduction in A1c, experienced an increase in the proinflammatory bacteria Megasphaera and Acidaminococcus, and only one beneficial genus, Phascolarctobacterium, increased, producer of butyrate.

CONCLUSION:

Despite a notable A1c outcome, G2 could not restore its MB. This seeming resistance to change, leading to a persistent inflammation component found in G2, might be part of the "metabolic memory" in T2DM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobinas Glicadas / Diabetes Mellitus Tipo 2 / Disbiose / Microbioma Gastrointestinal Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMJ Open Diabetes Res Care Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobinas Glicadas / Diabetes Mellitus Tipo 2 / Disbiose / Microbioma Gastrointestinal Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMJ Open Diabetes Res Care Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido