Your browser doesn't support javascript.
loading
Association of KLOTHO gene variants with metabolic and renal function parameters in Mexican patients living with type 2 diabetes.
Mendoza-Carrera, Francisco; Farías-Basulto, Alfonso; Gómez-García, Erika Fabiola; Rizo de la Torre, Lourdes Del Carmen; Cueto-Manzano, Alfonso Martin; Cortés-Sanabria, Laura; Pérez-Coria, Mariana; Vázquez-Rivera, Gloria Elizabeth.
Afiliação
  • Mendoza-Carrera F; División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada # 800, Col. Independencia, 44340 Guadalajara, Jalisco Mexico.
  • Farías-Basulto A; Unidad de Medicina Familiar no. 49, IMSS, Guadalajara, Mexico.
  • Gómez-García EF; Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Mexico.
  • Rizo de la Torre LDC; División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada # 800, Col. Independencia, 44340 Guadalajara, Jalisco Mexico.
  • Cueto-Manzano AM; Unidad de Investigación Biomédica 02, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Mexico.
  • Cortés-Sanabria L; Unidad de Investigación Biomédica 02, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Mexico.
  • Pérez-Coria M; División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada # 800, Col. Independencia, 44340 Guadalajara, Jalisco Mexico.
  • Vázquez-Rivera GE; División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada # 800, Col. Independencia, 44340 Guadalajara, Jalisco Mexico.
J Diabetes Metab Disord ; 23(1): 1125-1131, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38932797
ABSTRACT

Objective:

Type 2 diabetes (T2D) and high blood pressure are the main causes of chronic kidney disease (CKD) in adulthood. Both metabolic and oxidative stresses driven by hyperglycemia as well as genetic factors have been suggested as pathogenic causes of renal failure. Some single nucleotide variants (SNVs) on gene coding KLOTHO (KL) have been implicated in several clinical scenarios including hypertension, diabetes, and cardiovascular disease. The aim of this study was to analyze the association of rs1207568 (-395G > A), rs953614 (+ 1062T > G) and rs564481 (+ 1818 C > T) SNVs with metabolic and renal function parameters in Mexican patients living with type 2 diabetes.

Methods:

A cross-sectional study was conducted in 637 Mexican patients with T2D, and/or hypertension without previous diagnosis of CKD. Anthropometric, metabolic, and renal function parameters were determined. Patients were genotyped for rs1207568, rs953614 and rs564481 SNVs and associations under a dominant genetic model were analyzed by logistic regression.

Results:

For rs9536314, G-allele showed to be protective for hypo-HDL-C, albuminuria, and CKD. Carriers of minor allele of rs564481 had low odds for high glucose levels. No differences in genotype nor allele frequencies between the patients and the reference population were observed.

Conclusion:

In Mexican patients living with type 2 diabetes, KL variant rs9536314 was found associated with low odds of hypo-HDL cholesterol, albuminuria and presence of CKD. Meanwhile the consensus of soluble KLOTHO measurement is reached, genetic variants in the KL gene could be considered as genetic markers for CKD susceptibility in patients at high-risk of vascular complications.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: J Diabetes Metab Disord Ano de publicação: 2024 Tipo de documento: Article País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: J Diabetes Metab Disord Ano de publicação: 2024 Tipo de documento: Article País de publicação: Suíça