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Parasitic Effects on the Congenital Transmission of Trypanosoma cruzi in Mother-Newborn Pairs.
Herrera Choque, Ana Gabriela; Cuna, Washington R; Gabrielli, Simona; Mattiucci, Simonetta; Passera, Roberto; Rodriguez, Celeste.
Afiliação
  • Herrera Choque AG; Unidad de Inmunología Parasitaria, Facultad de Medicina, Universidad Mayor de San Andrés, La Paz, Bolivia.
  • Cuna WR; Unidad de Inmunología Parasitaria, Facultad de Medicina, Universidad Mayor de San Andrés, La Paz, Bolivia.
  • Gabrielli S; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Mattiucci S; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Passera R; Department of Medical Sciences, University of Torino, 10126 Torino, Italy.
  • Rodriguez C; Unidad de Inmunología Parasitaria, Facultad de Medicina, Universidad Mayor de San Andrés, La Paz, Bolivia.
Microorganisms ; 12(6)2024 Jun 20.
Article em En | MEDLINE | ID: mdl-38930625
ABSTRACT
Maternal parasitemia and placental parasite load were examined in mother-newborn pairs to determine their effect on the congenital transmission of Trypanosoma cruzi. Parasitemia was qualitatively assessed in mothers and newborns by the microhematocrit test; parasite load was determined in the placental tissues of transmitting and non-transmitting mothers by the detection of T. cruzi DNA and by histology. Compared to transmitter mothers, the frequency and prevalence of parasitemia were found to be increased in non-transmitter mothers; however, the frequency and prevalence of parasite load were higher among the transmitter mothers than among their non-transmitter counterparts. Additionally, serum levels of interferon (IFN)-γ were measured by an enzyme-linked immunosorbent assay (ELISA) in peripheral, placental, and cord blood samples. Median values of IFN-γ were significantly increased in the cord blood of uninfected newborns. The median IFN-γ values of transmitter and non-transmitter mothers were not significantly different; however, non-transmitter mothers had the highest total IFN-γ production among the group of mothers. Collectively, the results of this study suggest that the anti-T. cruzi immune response occurring in the placenta and cord is under the influence of the cytokines from the mother's blood and results in the control of parasitemia in uninfected newborns.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Microorganisms Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bolívia País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Microorganisms Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bolívia País de publicação: Suíça