Your browser doesn't support javascript.
loading
Differential phase-amplitude coupling in nucleus accumbens and orbitofrontal cortex reflects decision-making during a delay discounting task.
Azocar, V H; Petersson, P; Fuentes, R; Fuentealba, J A.
Afiliação
  • Azocar VH; School of Pharmacy and Interdisciplinary Center of Neuroscience, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Chile; Department of Neuroscience, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
  • Petersson P; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden; Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
  • Fuentes R; Department of Neuroscience, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
  • Fuentealba JA; School of Pharmacy and Interdisciplinary Center of Neuroscience, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Chile. Electronic address: jfuentea@uc.cl.
Prog Neuropsychopharmacol Biol Psychiatry ; 134: 111064, 2024 Aug 30.
Article em En | MEDLINE | ID: mdl-38917880
ABSTRACT

BACKGROUND:

The impulsive choice is characterized by the preference for a small immediate reward over a bigger delayed one. The mechanisms underlying impulsive choices are linked to the activity in the Nucleus Accumbens (NAc), the orbitofrontal cortex (OFC), and the dorsolateral striatum (DLS). While the study of functional connectivity between brain areas has been key to understanding a variety of cognitive processes, it remains unclear whether functional connectivity differentiates impulsive-control decisions.

METHODS:

To study the functional connectivity both between and within NAc, OFC, and DLS during a delay discounting task, we concurrently recorded local field potential in NAc, OFC, and DLS in rats. We then quantified the degree of phase-amplitude coupling (PAC), coherence, and Granger Causality between oscillatory activities in animals exhibiting either a high (HI) or low (LI) tendency for impulsive choices.

RESULTS:

Our results showed a differential pattern of PAC during decision-making in OFC and NAc, but not in DLS. While theta-gamma PAC in OFC was associated with self-control decisions, a higher delta-gamma PAC in both OFC and NAc biased decisions toward impulsive choices in both HI and LI groups. Furthermore, during the reward event, Granger Causality analysis indicated a stronger NAc➔OFC gamma contribution in the HI group, while the LI group showed a higher OFC➔NAc gamma contribution.

CONCLUSIONS:

The overactivity in NAc during reward in the HI group suggests that exacerbated contribution of NAcCore can lead to an overvaluation of reward that biases the behavior toward the impulsive choice.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recompensa / Córtex Pré-Frontal / Tomada de Decisões / Desvalorização pelo Atraso / Comportamento Impulsivo / Núcleo Accumbens Limite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recompensa / Córtex Pré-Frontal / Tomada de Decisões / Desvalorização pelo Atraso / Comportamento Impulsivo / Núcleo Accumbens Limite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido