IgG seroprevalence of Toxoplasma gondii and Leishmania infantum in leprosy patients: Implications for screening and management of co-infections.
Diagn Microbiol Infect Dis
; 110(1): 116405, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38906031
ABSTRACT
Parasitic co-infections are common in developing countries and can interfere with leprosy treatment, leading to an increased risk of inflammatory leprosy reactions. This study assessed serum immunoglobulin G (IgG) levels against Toxoplasma gondii and Visceral Leishmaniasis (VL) antigens in 270 leprosy patients from Brazilian states. Regarding the respective cut-offs, the prevalence of IgG seropositivity for T. gondii and VL were 21.05â¯% and 47.36â¯% in the leprosy-negative group, and 77.7â¯% and 52.6â¯% in the leprosy-positive group. Of the 270 leprosy patients, 158 (58.5â¯%) presented with inflammatory leprosy reactions. Of those, 72 (59.5â¯%) had neuritis, 35 (48.6â¯%) had reverse reactions, and 28 (38.9â¯%) had ENL in both Brazilian states. Leprosy patients with anti-Leishmania IgG seropositivity were 3.25 times more likely to develop neuritis (95â¯% C.I. 1.187 - 9.154; p = 0.019). These findings are particularly relevant for clinical settings where both leprosy and parasitic diseases are prevalent and could provide essential guidance for detecting and addressing complications arising from parasitic co-infections in leprosy patients, thereby improving clinical management strategies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxoplasma
/
Imunoglobulina G
/
Anticorpos Antiprotozoários
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Toxoplasmose
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Leishmania infantum
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Coinfecção
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Leishmaniose Visceral
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Hanseníase
Limite:
Adolescent
/
Adult
/
Aged
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Child
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Female
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Humans
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Male
/
Middle aged
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Diagn Microbiol Infect Dis
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Estados Unidos