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Proteins clump: Mechanics and transport during neurodegeneration.
Gazzo, David; Kinzer-Ursem, Tamara L; Zartman, Jeremiah J.
Afiliação
  • Gazzo D; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana; Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana.
  • Kinzer-Ursem TL; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.
  • Zartman JJ; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana; Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana. Electronic address: jzartman@nd.edu.
Biophys J ; 123(16): 2360-2362, 2024 Aug 20.
Article em En | MEDLINE | ID: mdl-38901429
ABSTRACT
This summary of recent contributions in the Biophysical Journal from 2020 to 2023 highlights new mechanistic insights into key biomechanical and biophysical aspects of neurodegeneration. Neurodegeneration encompasses complex diseases characterized by the progressive loss of neuronal function, often linked to protein accumulation and aggregation. Several factors, including mechanical properties and structural composition of brain tissue, formation of proteinaceous condensates within cells, and protein transport between cells, impact the loss of neural function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas Limite: Animals / Humans Idioma: En Revista: Biophys J Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas Limite: Animals / Humans Idioma: En Revista: Biophys J Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos