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Polycystic Ovary Syndrome, Metabolic Syndrome, and Inflammation in the Hispanic Community Health Study/Study of Latinos.
Rao, Hridya C; Meyer, Michelle L; Kominiarek, Michelle A; Daviglus, Martha L; Gallo, Linda C; Cordero, Christina; Syan, Raveen; Perreira, Krista M; Talavera, Gregory A; Fernández-Rhodes, Lindsay.
Afiliação
  • Rao HC; Department of Biobehavioral Health, Pennsylvania State University, University Park, PA.
  • Meyer ML; Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Kominiarek MA; Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL.
  • Daviglus ML; Department of Preventative Medicine, University of Illinois, Chicago, IL.
  • Gallo LC; Department of Psychology, San Diego State University, San Diego, CA.
  • Cordero C; Department of Psychology, University of Miami, Miami, FL.
  • Syan R; Department of Urology, University of Miami, Miami, FL.
  • Perreira KM; Department of Social Medicine, HCHS/SOL Coordinating Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Talavera GA; Department of Psychology, San Diego State University, San Diego, CA.
  • Fernández-Rhodes L; Department of Biobehavioral Health, Pennsylvania State University, University Park, PA.
J Clin Endocrinol Metab ; 2024 Jun 18.
Article em En | MEDLINE | ID: mdl-38888178
ABSTRACT
CONTEXT Polycystic Ovary Syndrome (PCOS) is a multifaceted endocrine disorder with reproductive and metabolic dysregulation. PCOS has been associated with inflammation and Metabolic Syndrome (MetS); however, the moderating effects of inflammation as measured by C-reactive protein (CRP) and menopause on the PCOS-MetS association have not been studied in Hispanic/Latinas with PCOS who have a higher metabolic burden.

OBJECTIVE:

We studied the cross-sectional association between PCOS and (i) MetS in 7316 females of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), (ii) subcomponents of MetS including impaired fasting glucose (IFG) and elevated triglycerides (TGL), and (iii) effect modification by menopausal status and CRP.

DESIGN:

HCHS/SOL is a multicenter, longitudinal, and observational study of US Hispanic/Latinos. Our study sample included females from Visit 2 with self-reported PCOS and MetS (ages 23-82 years).

RESULTS:

PCOS (prevalence=18.8%) was significantly associated with MetS prevalence (OR=1.41[95% confidence interval 1.13-1.76]), IFG and TGL (OR=1.42[1.18-1.72], OR=1.48[1.20-1.83] respectively). We observed effect modification by menopausal status (ORpre=1.46, pint=0.02; ORpost=1.34, pint=0.06) and CRP (ORelevated=1.41, pint=0.04; ORnormal=1.26, pint=0.16) on the PCOS-MetS association. We also observed a super-additive interaction between CRP and PCOS, adjusting for which resulted in an attenuated effect of PCOS on MetS (OR=1.29[0.93-1.78]).

CONCLUSIONS:

Hispanic/Latino females with PCOS had higher odds of MetS, IFG, and elevated TGL, than their peers without PCOS. Interaction analyses revealed that the odds of MetS are higher among PCOS females who have pre-menopausal status or high inflammation. Interventions in Hispanic/Latinas should target these outcomes for effective management of the disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos