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Effect of ammonium on chloramphenicol production by Streptomyces venezuelae in batch and continuous cultures.
Can J Microbiol ; 31(2): 119-23, 1985 Feb.
Article em En | MEDLINE | ID: mdl-3886114
Cultures of Streptomyces venezuelae presented with a mixture of ammonium and an amino acid as nitrogen sources used both compounds together. Absence of ammonium repression of alternative nitrogen assimilation pathways was also observed when ammonium was added to cultures already growing on proline. The presence of ammonium in the medium ab initio depressed the yield of chloramphenicol. However, its addition to a culture growing on proline caused only a temporary inhibition of antibiotic synthesis, even when sufficient ammonium was added to create an excess. Continuous cultures supplied with ammonium as the growth-limiting nutrient showed no significant change in specific antibiotic production at different specific growth rates. The overall results indicate that in S. venezuelae neither nitrogen utilization pathways nor chloramphenicol biosynthesis is controlled by nitrogen repression.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptomyces / Cloranfenicol / Compostos de Amônio Quaternário País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Can J Microbiol Ano de publicação: 1985 Tipo de documento: Article País de publicação: Canadá
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptomyces / Cloranfenicol / Compostos de Amônio Quaternário País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Can J Microbiol Ano de publicação: 1985 Tipo de documento: Article País de publicação: Canadá