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Analysis of PD-1/PD-L1 variations in lung cancer and association with immunotherapeutic efficacy and prognosis: A nonrandomized controlled trial.
Ma, Jun; Song, JianRui; Han, LiNa; Zhou, Wen; Meng, LiFeng; Li, JianHui; Bai, XiaoMing.
Afiliação
  • Ma J; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Shuangta Temple Street, Taiyuan City, Shanxi Province, China. Electronic address: majun2008@gzhmu-edu.cn.
  • Song J; Wisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou City, Jiangsu Province, China.
  • Han L; Office of Health Emergency, Shanxi Provincial People's Hospital, Fifth Clinical Medical College, Shanxi Medical University, Taiyuan City, Shanxi Province, China.
  • Zhou W; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Shuangta Temple Street, Taiyuan City, Shanxi Province, China.
  • Meng L; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Shuangta Temple Street, Taiyuan City, Shanxi Province, China.
  • Li J; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Shuangta Temple Street, Taiyuan City, Shanxi Province, China.
  • Bai X; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Shuangta Temple Street, Taiyuan City, Shanxi Province, China.
Clinics (Sao Paulo) ; 79: 100395, 2024.
Article em En | MEDLINE | ID: mdl-38852543
ABSTRACT

INTRODUCTION:

This study aims to explore Programmed Death Receptor-1 (PD-1) and Programmed Death Ligand-1 (PD-L1) variations in Lung Cancer (LC) tissues and Peripheral Blood (PPB) and their association with immunotherapy efficacy and prognosis.

METHOD:

72 patients with LC were included in the LC group and 39 patients with concurrent benign lung disease were included in the benign group. PD-1/PDL-1 was compared in PPB and lung tissue. All LC patients were treated with immunotherapy. The relationship between PD-1/PDL-1 in LC tissue and PPB and immunotherapy efficacy was analyzed. Patients were divided into death and survival groups, and PD-1/PDL-1 in tumor tissues and PPB were compared.

RESULTS:

The authors found that PD-1 and PDL-1 positive expression in lung tissue and PPB in LC patients was elevated. Combined detection of PD-1 and PDL-1 was effective in diagnosing LC and evaluating the prognosis of LC patients. PD-1 and PDL-1 positive expression was reduced after disease remission while elevated in dead patients. The 3-year survival rate of patients with PD-1 positive expression was 45.45 % (25/55), which was lower (82.35 %, 14/17) than those with PD-1 negative expression. The 3-year survival rate of patients with positive and negative expression of PDL-1 was 48.78 % (20/41) and 61.29 % (19/31), respectively.

DISCUSSION:

The present results demonstrated that PD-1 and PDL-1 are abnormal in cancer tissue and PPB of LC patients. The combined detection of PD-1 and PDL-1 has diagnostic value for LC and evaluation value for the efficacy and prognosis of immunotherapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígeno B7-H1 / Receptor de Morte Celular Programada 1 / Imunoterapia / Neoplasias Pulmonares Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígeno B7-H1 / Receptor de Morte Celular Programada 1 / Imunoterapia / Neoplasias Pulmonares Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos