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Fetal Hyperthyroidism Secondary to Maternal Basedow-Graves' Disease.
Soto, Julio; Weissglas, Bunio; von Plessing-Pierry, Gustav; Del Solar, Maria Paz; Peña-Villa, Carolina; Flores, Ximena; Arancibia, Monica; Campos, Laura.
Afiliação
  • Soto J; Department of Pediatrics, School of Medicine, Universidad de Concepcion, Concepcion, Chile.
  • Weissglas B; Division of Pediatric Endocrinology, Pediatrics Service, Hospital Las Higueras, Talcahuano, Chile.
  • von Plessing-Pierry G; Department of Internal Medicine, School of Medicine, Universidad de Concepcion, Concepcion, Chile.
  • Del Solar MP; Department of Internal Medicine, School of Medicine, Universidad de Concepcion, Concepcion, Chile.
  • Peña-Villa C; Department of Clinical and Preclinical Sciences, School of Medicine, Universidad Catolica de la Santisima Concepcion, Concepcion, Chile.
  • Flores X; Department of Internal Medicine, School of Medicine, Universidad de Concepcion, Concepcion, Chile.
  • Arancibia M; Division of Endocrinology, Internal Medicine Service, Hospital Las Higueras, Talcahuano, Chile.
  • Campos L; Division of Obstetric and Gynecologic Ultrasound, Obstetrics and Gynecology Service, Hospital Las Higueras, Talcahuano, Chile.
AJP Rep ; 14(2): e176-e183, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38827649
ABSTRACT
Fetal hyperthyroidism is a rare prenatal disease and can be life-threatening. The diagnosis is based on ultrasound in mothers with a history of Basedow-Graves' disease and elevation of thyrotropin receptor antibodies (TRAbs) levels. The treatment consists of antithyroid drugs. We present a mother with Basedow-Graves' disease, treated with radioactive iodine 16 years ago. She had an unplanned pregnancy at the age of 29 years, and an elevation of TRAbs (21 U/L) was found at the sixth week of pregnancy. At 22 weeks of gestation, fetal ultrasound displayed tachycardia, goiter, exophthalmos, and suspicion of craniosynostosis, hence methimazole was started. Concomitantly, suppressed maternal thyroid-stimulating hormone (TSH) was found. Her daughter was born at 33 + 6 weeks showing clinical and laboratory findings of hyperthyroidism. Consequently, treatment with methimazole was prescribed. Normal thyroid function was documented in the mother after giving birth. Clear explanation has not been found for the alteration of maternal TSH during pregnancy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: AJP Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: AJP Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos