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Increasing community prevalence of extended-spectrum beta-lactamase-producing Escherichia coli in urine is associated with increasing district-level antibiotic consumption.
Nunes, Larissa Hermann de Souza; Ribeiro, Victoria Stadler Tasca; Salviato, Rafael Buttini; de Andrade, Ana Paula; Suss, Paula Hansen; Vicenzi, Fernando José; Hino, Adriano Akira Ferreira; Telles, João Paulo; Tuon, Felipe Francisco.
Afiliação
  • Nunes LHS; Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná 80215-901, Brazil.
  • Ribeiro VST; Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná 80215-901, Brazil.
  • Salviato RB; Universidade Federal do Paraná, Applied Social Sciences Sector, Department of Economics, Curitiba, Paraná  80210-170, Brazil.
  • de Andrade AP; Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná 80215-901, Brazil.
  • Suss PH; Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná 80215-901, Brazil.
  • Vicenzi FJ; Municipal Laboratory of Curitiba, Curitiba, Paraná 81050-290, Brazil.
  • Hino AAF; Pontifícia Universidade Católica do Paraná. Graduate Program in Health Sciences (PPGCS), School of Medicine, Research Group on Physical Activity and Quality of Life. Curitiba, Paraná 80215-901, Brazil.
  • Telles JP; Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná 80215-901, Brazil.
  • Tuon FF; Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná 80215-901, Brazil.
FEMS Microbiol Lett ; 3712024 Jan 09.
Article em En | MEDLINE | ID: mdl-38821516
ABSTRACT
This study aimed to analyze ESBL-producing Escherichia coli prevalence in urine samples collected between 2011-2019 in Curitiba, a large city in Brazil, and relating it to antibiotic consumption and sanitary conditions. This is a longitudinal study correlating prevalence of ESBL-producing E. coli isolates from urine samples with district-level antibiotic consumption and sociodemographic data during 2011-2019. E. coli isolates were tested for antibiotic susceptibility and ESBL by an automated method. Statistical analysis applied linear regressions, pooled ordinary least squares, and fixed effects models for districts or years. The Chow and Hausman tests indicated that the fixed effects model for individual districts fitted best. Chi-square test was used for qualitative variables (statistical significance was set when P < 0.05). Among the 886 535 urine sample cultures, 9.9% of isolates were ESBL-producing E. coli. Their prevalence increased from 4.7% in 2012 to 19.3% in 2019 (P < 0.0001; R2 = 0.922). This progressive increase correlated with age (P = 0.007; R2 = 0.8725) and male gender (P < 0.001) and increased antibiotic consumption (P = 0.0386; R2 = 0.47). The fixed effects model showed that district influences ESBL prevalence and that antibiotic consumption explains 20%-30% of this variation, with an increase of one defined daily dose accounting for an increase of 0.02084 percentage points of ESBL. The increasing prevalence of ESBL-producing E. coli can, to a considerable extent, be explained by increasing antibiotic consumption.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Escherichia coli / Infecções por Escherichia coli / Antibacterianos Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: FEMS Microbiol Lett Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Escherichia coli / Infecções por Escherichia coli / Antibacterianos Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: FEMS Microbiol Lett Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido