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New insights into sodium phenylbutyrate as a pharmacotherapeutic option for neurological disorders.
Juarez, Daniel; Handal-Silva, Anabella; Morán-Perales, Jose Luis; Torres-Cifuentes, Diana M; Flores, Gonzalo; Treviño, Samuel; Moreno-Rodriguez, Albino; Guevara, Jorge; Diaz, Alfonso.
Afiliação
  • Juarez D; Faculty of Chemical Sciences, Benemeritus Autonomous University of Puebla, Puebla, Puebla, Mexico.
  • Handal-Silva A; Department of Reproductive Biology and Toxicology, Institute of Sciences. Benemeritus Autonomous University of Puebla, Puebla, Puebla, Mexico.
  • Morán-Perales JL; Department of Reproductive Biology and Toxicology, Institute of Sciences. Benemeritus Autonomous University of Puebla, Puebla, Puebla, Mexico.
  • Torres-Cifuentes DM; Faculty of Chemical Sciences, Benemeritus Autonomous University of Puebla, Puebla, Puebla, Mexico.
  • Flores G; Institute of Physiology, Benemeritus Autonomous University of Puebla, Puebla, Puebla, Mexico.
  • Treviño S; Institute of Physiology, Benemeritus Autonomous University of Puebla, Puebla, Puebla, Mexico.
  • Moreno-Rodriguez A; Faculty of Chemical Sciences, Benemeritus Autonomous University of Puebla, Puebla, Puebla, Mexico.
  • Guevara J; Faculty of Medicine, Department of Biochemistry, National Autonomous University of Mexico, Mexico City, Mexico.
  • Diaz A; Institute of Physiology, Benemeritus Autonomous University of Puebla, Puebla, Puebla, Mexico.
Synapse ; 78(4): e22301, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38819491
ABSTRACT
Neurological disorders (NDs) are diseases of the central and peripheral nervous systems that affect more than one billion people worldwide. The risk of developing an ND increases with age due to the vulnerability of the different organs and systems to genetic, environmental, and social changes that consequently cause motor and cognitive deficits that disable the person from their daily activities and individual and social productivity. Intrinsic factors (genetic factors, age, gender) and extrinsic factors (addictions, infections, or lifestyle) favor the persistence of systemic inflammatory processes that contribute to the evolution of NDs. Neuroinflammation is recognized as a common etiopathogenic factor of ND. The study of new pharmacological options for the treatment of ND should focus on improving the characteristic symptoms and attacking specific molecular targets that allow the delay of damage processes such as neuroinflammation, oxidative stress, cellular metabolic dysfunction, and deregulation of transcriptional processes. In this review, we describe the possible role of sodium phenylbutyrate (NaPB) in the pathogenesis of Alzheimer's disease, hepatic encephalopathy, aging, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis; in addition, we describe the mechanism of action of NaPB and its beneficial effects that have been shown in various in vivo and in vitro studies to delay the evolution of any ND.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilbutiratos / Doenças do Sistema Nervoso Limite: Animals / Humans Idioma: En Revista: Synapse Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilbutiratos / Doenças do Sistema Nervoso Limite: Animals / Humans Idioma: En Revista: Synapse Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos