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Tracing the evolution of the chikungunya virus in Argentina, 2016-2023: independent introductions and prominence of Latin American lineages.
Fabbri, Cintia; Giovanetti, Marta; Luppo, Victoria; Fonseca, Vagner; Garcia, Jorge; Barulli, Cintia; Feroci, Mariel; Perrone, Sofia; Casoni, Doraldina; Giamperetti, Sergio; Alvarez Lopez, Maria Cristina; Foussal, Maria Delia; Figueredo, Mauricio; Salvatierra, Karina; Lejona, Sergio; Ruiz Diaz, Natalia; Castro, Gonzalo; Bravo, Gabriela; Jackel, Noelia; Sen, Carina; Poklepovich Caride, Tomás; Franco, Leticia; Giovachini, Carlos; Mendez Rico, Jairo; Alcantara, Luiz Carlos Junior; Morales, Maria Alejandra.
Afiliação
  • Fabbri C; Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui", ANLIS, Pergamino, Argentina.
  • Giovanetti M; Department of Sciences and Technologies for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Rome, Italy.
  • Luppo V; Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
  • Fonseca V; Climate Amplified Diseases and Epidemics (CLIMADE), Minas Gerais, Brazil.
  • Garcia J; Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui", ANLIS, Pergamino, Argentina.
  • Barulli C; Climate Amplified Diseases and Epidemics (CLIMADE), Minas Gerais, Brazil.
  • Feroci M; Departamento de Ciências Exatas e da Terra, Universidade do Estado da Bahia, Salvador, Brazil.
  • Perrone S; Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui", ANLIS, Pergamino, Argentina.
  • Casoni D; Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui", ANLIS, Pergamino, Argentina.
  • Giamperetti S; Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui", ANLIS, Pergamino, Argentina.
  • Alvarez Lopez MC; Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui", ANLIS, Pergamino, Argentina.
  • Foussal MD; Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui", ANLIS, Pergamino, Argentina.
  • Figueredo M; Hospital de Infecciosas Francisco Javier Muñiz, CABA, Buenos Aires, Argentina.
  • Salvatierra K; Hospital General de Niños R. Gutiérrez, CABA, Buenos Aires, Argentina.
  • Lejona S; Hospital Julio C. Perrando, Chaco, Argentina.
  • Ruiz Diaz N; Hospital de Alta Complejidad "Pte. Juan Domingo Perón", Formosa, Argentina.
  • Castro G; Laboratorio de Alta Complejidad de Posadas, Misiones, Argentina.
  • Bravo G; CEMAR - Secretaria de Salud - Municipalidad de Rosario, Santa Fe, Argentina.
  • Jackel N; Laboratorio Central de Redes y Programas de Corrientes, Corrientes, Argentina.
  • Sen C; Laboratorio Central de la Provincia de Cordoba, Córdoba, Argentina.
  • Poklepovich Caride T; Hospital Señor del Milagro, Salta, Argentina.
  • Franco L; Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui", ANLIS, Pergamino, Argentina.
  • Giovachini C; Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui", ANLIS, Pergamino, Argentina.
  • Mendez Rico J; Unidad Operativa, Centro Nacional de Genómica y Bioinformática, ANLIS.
  • Alcantara LCJ; Infectious Hazards Management, Health Emergencies Department (PHE), Pan American Health Organi-zation/World Health Organization (PAHO/WHO), Washington, DC, USA.
  • Morales MA; Direccion de Epidemiologia, Minsiterio de Salud de la Nacion, Buenos Aires, Argentina.
Emerg Microbes Infect ; 13(1): 2362941, 2024 Dec.
Article em En | MEDLINE | ID: mdl-38813649
ABSTRACT
Chikungunya virus (CHIKV) has emerged as a significant public health concern due to its rapid spread and potential for causing debilitating epidemics. In Argentina, the virus has garnered attention since its introduction to the Americas in 2013, due to its growing incidence and impact in neighbouring countries. Here we present a comprehensive analysis of the spatiotemporal dynamics of CHIKV in Argentina, focusing on the evolutionary trajectory of its genetic variants. Through a combination of active surveillance, screening of historical and recent samples, and whole-genome sequencing, we traced the evolutionary history of CHIKV lineages circulating within the country. Our results reveal that two distinct genotypes circulated in Argentina The Asian lineage during the 2016 epidemic and the ECSA lineage in 2023. This distribution reflects the dominance of particular variants across Latin America. Since 2023, the ECSA lineage has led to a surge in cases throughout the Americas, marking a significant shift. The replacement of lineages in the American region constitutes a major epidemiological event, potentially affecting the dynamics of virus transmission and the clinical outcomes in impacted populations. The spatiotemporal analysis highlights CHIKV's distribution across Argentina and underscores the significant role of human mobility, especially when considering recent epidemics in neighbouring countries such as Paraguay and Uruguay, which have facilitated the spread and introduction of the viral strain into different districts. By integrating epidemiological data with genomic insights, we elucidate the patterns of virus dissemination, highlighting key areas of transmission and potential factors contributing to its spread.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Vírus Chikungunya / Evolução Molecular / Febre de Chikungunya / Genótipo Limite: Humans País/Região como assunto: America do sul / Argentina Idioma: En Revista: Emerg Microbes Infect Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Vírus Chikungunya / Evolução Molecular / Febre de Chikungunya / Genótipo Limite: Humans País/Região como assunto: America do sul / Argentina Idioma: En Revista: Emerg Microbes Infect Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos