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The Placental Role in Gestational Diabetes Mellitus: A Molecular Perspective.
Calvo, María José; Parra, Heliana; Santeliz, Raquel; Bautista, Jordan; Luzardo, Eliana; Villasmil, Nelson; Martínez, María Sofía; Chacín, Maricamen; Cano, Clímaco; Checa-Ros, Ana; D'Marco, Luis; Bermúdez, Valmore; De Sanctis, Juan Bautista.
Afiliação
  • Calvo MJ; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela.
  • Parra H; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela.
  • Santeliz R; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela.
  • Bautista J; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela.
  • Luzardo E; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela.
  • Villasmil N; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela.
  • Martínez MS; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela.
  • Chacín M; Facultad de Ciencias de la Salud, Barranquilla, Universidad Simón Bolívar, Barranquilla, Colombia.
  • Cano C; Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela.
  • Checa-Ros A; Research Group on Cardiorenal and Metabolic Diseases, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
  • D'Marco L; School of Life and Health Sciences, Aston University, Birmingham, United Kingdom.
  • Bermúdez V; Research Group on Cardiorenal and Metabolic Diseases, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
  • De Sanctis JB; Facultad de Ciencias de la Salud, Barranquilla, Universidad Simón Bolívar, Barranquilla, Colombia.
touchREV Endocrinol ; 20(1): 10-18, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38812661
ABSTRACT
During pregnancy, women undergo several metabolic changes to guarantee an adequate supply of glucose to the foetus. These metabolic modifications develop what is known as physiological insulin resistance. When this process is altered, however, gestational diabetes mellitus (GDM) occurs. GDM is a multifactorial disease, and genetic and environmental factors play a crucial role in its aetiopathogenesis. GDM has been linked to both macroscopic and molecular alterations in placental tissues that affect placental physiology. This review summarizes the role of the placenta in the development of GDM from a molecular perspective, including hormonal and pro-inflammatory changes. Inflammation and hormonal imbalance, the characteristics dominating the GDM microenvironment, are responsible for placental changes in size and vascularity, leading to dysregulation in maternal and foetal circulations and to complications in the newborn. In conclusion, since the hormonal mechanisms operating in GDM have not been fully elucidated, more research should be done to improve the quality of life of patients with GDM and their future children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: TouchREV Endocrinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: TouchREV Endocrinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Reino Unido