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The impact of cannabis use proximal to sleep and cannabinoid metabolites on sleep architecture.
Althoff, Meghan D; Kinney, Gregory L; Aloia, Mark S; Sempio, Cristina; Klawitter, Jost; Bowler, Russell P.
Afiliação
  • Althoff MD; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
  • Kinney GL; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
  • Aloia MS; Division of Pulmonary, Critical Care & Sleep Medicine, National Jewish Health, Denver, Colorado.
  • Sempio C; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
  • Klawitter J; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
  • Bowler RP; Division of Pulmonary, Critical Care & Sleep Medicine, National Jewish Health, Denver, Colorado.
J Clin Sleep Med ; 20(10): 1615-1625, 2024 Oct 01.
Article em En | MEDLINE | ID: mdl-38804689
ABSTRACT
STUDY

OBJECTIVES:

Cannabis is a common sleep aid; however, the effects of its use prior to sleep are poorly understood. This study aims to determine the impact of nonmedical whole plant cannabis use 3 hours prior to sleep and measured cannabis metabolites on polysomnogram measures.

METHODS:

This is a cross-sectional study of 177 healthy adults who provided detailed cannabis use history, underwent a 1-night home sleep test and had measurement of 11 plasma and urinary cannabinoids, quantified using mass spectroscopy, the morning after the home sleep test. Multivariable models were used to assess the relationship between cannabis use proximal to sleep, which was defined as use 3 hours before sleep, and individual home sleep test measurements. Correlation between metabolite concentrations and polysomnogram measures were assessed.

RESULTS:

In adjusted models, cannabis use proximal to sleep was associated with increased wake after sleep onset (median 60.5 vs 45.8 minutes), rate ratio 1.59 (1.22, 2.05), and increased proportion of stage 1 sleep (median 15.2% vs 12.3%), effect estimate 0.16 (0.06, 0.25). Compared to nonusers, frequent cannabis users (> 20 days per month) also had increased wake after sleep onset and stage 1 sleep, in addition to increased rapid eye movement latency and decreased percent sleep efficiency. Δ9-tetrahydrocannabinol metabolites correlated with these home sleep test measures.

CONCLUSIONS:

Cannabis use proximal to sleep was associated with minimal changes in sleep architecture. Its use was not associated with measures of improved sleep including increased sleep time or efficiency and may be associated with poor quality sleep through increased wake onset and stage 1 sleep. CITATION Althoff MD, Kinney GL, Aloia MS, Sempio C, Klawitter J, Bowler RP. The impact of cannabis use proximal to sleep and cannabinoid metabolites on sleep architecture. J Clin Sleep Med. 2024;20(10)1615-1625.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Canabinoides / Polissonografia Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Sleep Med Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Canabinoides / Polissonografia Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Sleep Med Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos