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Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero.
Fajardo-Martinez, Viviana; Ferreira, Fatima; Fuller, Trevon; Cambou, Mary Catherine; Kerin, Tara; Paiola, Sophia; Mok, Thalia; Rao, Rashmi; Mohole, Jyodi; Paravastu, Ramya; Zhang, Dajie; Marschik, Peter; Iyer, Sai; Kesavan, Kalpashri; Borges Lopes, Maria da Conceição; Britto, José Augusto A; Moreira, Maria Elisabeth; Brasil, Patricia; Nielsen-Saines, Karin.
Afiliação
  • Fajardo-Martinez V; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Ferreira F; Universidade do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Fuller T; UCLA Institute for the Environment and Sustainability, Los Angeles, CA, USA. fullertl@ucla.edu.
  • Cambou MC; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Kerin T; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Paiola S; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Mok T; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Rao R; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Mohole J; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Paravastu R; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Zhang D; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany.
  • Marschik P; Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen and Leibniz ScienceCampus Primate Cognition, Göttingen, Germany.
  • Iyer S; Interdisciplinary Developmental Neuroscience (IDN), Division of Phoniatrics, Medical University of Graz, Graz, Austria.
  • Kesavan K; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany.
  • Borges Lopes MDC; Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen and Leibniz ScienceCampus Primate Cognition, Göttingen, Germany.
  • Britto JAA; Interdisciplinary Developmental Neuroscience (IDN), Division of Phoniatrics, Medical University of Graz, Graz, Austria.
  • Moreira ME; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Brasil P; David Geffen, UCLA School of Medicine, Los Angeles, CA, USA.
  • Nielsen-Saines K; Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
Sci Rep ; 14(1): 11851, 2024 05 24.
Article em En | MEDLINE | ID: mdl-38789553
ABSTRACT
It is unclear if SARS CoV-2 infection during pregnancy is associated with adverse neurodevelopmental repercussions to infants. We assessed pediatric neurodevelopmental outcomes in children born to mothers with laboratory-confirmed SARS CoV-2 infection during pregnancy. Neurodevelopmental outcomes of in-utero exposed children were compared to that of pre-pandemic control children in Los Angeles (LA), CA, USA and Rio de Janeiro, Brazil. Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III), the gold standard tool for evaluating neurodevelopment until 36 months of age and Ages and Stages Questionnaires (ASQ-3), a frequently used screening instrument for evaluating neurodevelopment in this same age group were the assessment tools used. Developmental delay (DD) was defined as having a score < - 2 SD below the norm (< 70) in at least one of three Bayley-III domains, (cognitive, motor or language) or a score below the cut-off (dark zone) in at least one of five ASQ-3 domains (communication, gross motor, fine motor, problem solving, personal-social). Exposed children were born between April 2020 and December 2022 while control children were born between January 2016 to December 2019. Neurodevelopmental testing was performed in 300 children total 172 COVID-19 exposed children between 5-30 months of age and 128 control children between 6-38 months of age. Bayley-III results demonstrated that 12 of 128 exposed children (9.4%) had DD versus 2 of 128 controls (1.6%), p = 0.0007. Eight of 44 additional exposed children had DD on ASQ-3 testing. Fully, 20 of 172 exposed children (11.6%) and 2 of 128 control children (1.6%), p = 0.0006 had DD. In Rio, 12% of exposed children versus 2.6% of controls, p = 0.02 had DD. In LA, 5.7% of exposed children versus 0 controls, p = 0.12 had DD. Severe/critical maternal COVID-19 predicted below average neurodevelopment in the exposed cohort (OR 2.6, 95% CI 1.1-6.4). Children exposed to antenatal COVID-19 have a tenfold higher frequency of DD as compared to controls and should be offered neurodevelopmental follow-up.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Efeitos Tardios da Exposição Pré-Natal / Deficiências do Desenvolvimento / SARS-CoV-2 / COVID-19 Limite: Adult / Child, preschool / Female / Humans / Infant / Male / Pregnancy País/Região como assunto: America do norte / America do sul / Brasil Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Efeitos Tardios da Exposição Pré-Natal / Deficiências do Desenvolvimento / SARS-CoV-2 / COVID-19 Limite: Adult / Child, preschool / Female / Humans / Infant / Male / Pregnancy País/Região como assunto: America do norte / America do sul / Brasil Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido