CORRELATION OF LEPTIN AND ADIPONECTIN RECEPTOR EXPRESSION WITH CLINICOPATHOLOGICAL PARAMETERS IN COLORECTAL CARCINOMA - A CROSS-SECTIONAL PROSPECTIVE STUDY.

Parmesh, Priyanka; Dinesh, Udupi Shastri; Khandagale, Ajay S; Bapu, Anil Bargale; Sadashiv, Roshni; Reddy, Pradnya

Parmesh, Priyanka; Dinesh, Udupi Shastri; Khandagale, Ajay S; Bapu, Anil Bargale; Sadashiv, Roshni; Reddy, Pradnya.

Afiliação

Parmesh P; Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.
Dinesh US; Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.
Khandagale AS; Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.
Bapu AB; Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.
Sadashiv R; Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.
Reddy P; Department of Laboratory Medicine, Victor hospital, Margao, Goa, India.

Arq Gastroenterol ; 61: e24016, 2024.

Article em En | MEDLINE | ID: mdl-38775586

ABSTRACT

ABSTRACT

BACKGROUND:

Colorectal carcinoma (CRC) is one of the common carcinomas with a rising incidence of metastasis due to its advanced stage of presentation. The existing biomarkers such as CEA (Carcinoembryonic antigen) etc., for prognosis, have low sensitivity and specificity. Hence a need for a newer definitive biomarker. Obesity is the leading cause of CRC. Leptin and adiponectin secreted by adipose tissue have been studied as potential biomarkers in the field of CRC. The present study helps to understand the association of leptin and adiponectin receptors with clinicopathological parameters.

OBJECTIVE:

To correlate the various clinicopathological parameters with the tissue expression of leptin and adiponectin receptors in CRC.

METHODS:

It is a cross-sectional prospective study conducted at a tertiary care hospital. Formalin fixed paraffin blocks of all radical resection CRC cases were collected and immunohistochemistry (IHC)was carried out on tumor tissue for leptin and adiponectin receptor. Tumor characteristics and clinical parameters were collected from the hospital medical records. Pearson's correlation coefficient test was used.

RESULTS:

Immunohistochemistry was performed on 60 cases of CRC. Significant positive correlation of leptin was observed with size, lymph node metastasis, advanced stage, and grade of tumor (P<0.05). A significant correlation between adiponectin receptor and CRC was observed concerning age, stage, lymph node metastasis, distant metastasis and grade of tumor.

CONCLUSION:

Positive expression of leptin and negative expression of adiponectin receptors in CRC helps to predict the risk of metastasis.

Assuntos

Biomarcadores Tumorais; Neoplasias Colorretais; Imuno-Histoquímica; Leptina; Estadiamento de Neoplasias; Receptores de Adiponectina; Humanos; Neoplasias Colorretais/patologia; Neoplasias Colorretais/metabolismo; Estudos Transversais; Estudos Prospectivos; Masculino; Feminino; Pessoa de Meia-Idade; Leptina/metabolismo; Leptina/análise; Receptores de Adiponectina/análise; Receptores de Adiponectina/metabolismo; Idoso; Biomarcadores Tumorais/metabolismo; Adulto; Receptores para Leptina/metabolismo; Receptores para Leptina/análise; Gradação de Tumores; Metástase Linfática

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imuno-Histoquímica / Neoplasias Colorretais / Biomarcadores Tumorais / Leptina / Receptores de Adiponectina / Estadiamento de Neoplasias Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil

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