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Assessment of serum granulysin and cathepsin-L levels in vitiligo patients.
Yazar, Cemre; Akbayrak, Atiye; Ozmen, Zeliha Cansel; Kuyucu, Yunus Emre; Sencan, Mehtap; Kutlu, Omer; Seckin, Havva Yildiz.
Afiliação
  • Yazar C; Gaziosmanpasa University, School of Medicine, Department of Dermatology and Venereology - Tokat, Turkey.
  • Akbayrak A; Gaziosmanpasa University, School of Medicine, Department of Dermatology and Venereology - Tokat, Turkey.
  • Ozmen ZC; Gaziosmanpasa University, School of Medicine, Department of Biochemistry - Tokat, Turkey.
  • Kuyucu YE; Gaziosmanpasa University, School of Medicine, Department of Biostatistics - Tokat, Turkey.
  • Sencan M; Dortyol State Hospital - Dörtyol, Turkey.
  • Kutlu O; Gaziosmanpasa University, School of Medicine, Department of Dermatology and Venereology - Tokat, Turkey.
  • Seckin HY; Gaziosmanpasa University, School of Medicine, Department of Dermatology and Venereology - Tokat, Turkey.
Rev Assoc Med Bras (1992) ; 70(5): e20231107, 2024.
Article em En | MEDLINE | ID: mdl-38775500
ABSTRACT

OBJECTIVE:

Cellular and humoral immunity plays a role in the pathogenesis of vitiligo. T lymphocytes and natural killer cells involved in cellular immunity carry out their cytotoxic activities through perforin/granzyme-dependent granule exocytosis, in which granulysin and cathepsin-L are also involved. The aim of this study was to investigate the possible role of serum granulysin and cathepsin-L in the etiopathogenesis of vitiligo and their association with disease activity and severity.

METHODS:

This randomized, prospective case-control study was conducted with 46 vitiligo patients admitted to the hospital for vitiligo between January and November 2021 and 46 healthy volunteers of similar age and gender. Serum levels of granulysin and cathepsin-L were measured by the enzyme-linked immunosorbent assay method.

RESULTS:

The mean serum levels of granulysin and cathepsin-L were statistically significantly higher in vitiligo patients compared with the control group (p=0.048 and p=0.024, respectively). There was no statistically significant correlation between serum granulysin and serum cathepsin-L levels and disease severity in the patient group (r=0.30, p=0.062 and r=0.268, p=0.071, respectively). Disease activity also showed no significant association with serum granulysin and cathepsin-L levels (p=0.986 and p=0.962, respectively).

CONCLUSION:

Although granulysin and cathepsin-L are molecules involved in the pathogenesis of vitiligo, the use of these molecules may not be helpful in assessing disease activity and severity. It may be helpful to conduct comprehensive and prospective studies to find new molecules to fill the gap in this area.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitiligo / Índice de Gravidade de Doença / Antígenos de Diferenciação de Linfócitos T / Catepsina L Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitiligo / Índice de Gravidade de Doença / Antígenos de Diferenciação de Linfócitos T / Catepsina L Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil