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5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats.
Souza, Annie C; Souza, Bryan C; França, Arthur; Moradi, Marzieh; Souza, Nicholy C; Leão, Katarina E; Tort, Adriano B L; Leão, Richardson N; Lopes-Dos-Santos, Vítor; Ribeiro, Sidarta.
Afiliação
  • Souza AC; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Souza BC; Department of Psychology, Florida State University, Tallahassee, USA.
  • França A; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Moradi M; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
  • Souza NC; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Leão KE; Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
  • Tort ABL; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Leão RN; Department of Neuroscience and Behavioural Sciences, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
  • Lopes-Dos-Santos V; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Ribeiro S; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Sci Rep ; 14(1): 11281, 2024 05 17.
Article em En | MEDLINE | ID: mdl-38760450
ABSTRACT
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in rodents. However, there is limited knowledge regarding its acute neurophysiological effects. Local field potentials (LFPs) are commonly used as a proxy for neural activity, but previous studies investigating psychedelics have been hindered by confounding effects of behavioural changes and anaesthesia, which alter these signals. To address this gap, we investigated acute LFP changes in the hippocampus (HP) and medial prefrontal cortex (mPFC) of freely behaving rats, following 5-MeO-DMT administration. 5-MeO-DMT led to an increase of delta power and a decrease of theta power in the HP LFPs, which could not be accounted for by changes in locomotion. Furthermore, we observed a dose-dependent reduction in slow (20-50 Hz) and mid (50-100 Hz) gamma power, as well as in theta phase modulation, even after controlling for the effects of speed and theta power. State map analysis of the spectral profile of waking behaviour induced by 5-MeO-DMT revealed similarities to electrophysiological states observed during slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep. Our findings suggest that the psychoactive effects of classical psychedelics are associated with the integration of waking behaviours with sleep-like spectral patterns in LFPs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Vigília / Córtex Pré-Frontal / Hipocampo Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Vigília / Córtex Pré-Frontal / Hipocampo Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido