The Future of Atopic Dermatitis Treatment.

Lovell, Katie; Patel, Nupur; Rao, Saroja; Strowd, Lindsay C

Lovell, Katie; Patel, Nupur; Rao, Saroja; Strowd, Lindsay C.

Afiliação

Lovell K; Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Patel N; Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Rao S; Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Strowd LC; Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Adv Exp Med Biol ; 1447: 227-244, 2024.

Article em En | MEDLINE | ID: mdl-38724797

ABSTRACT

ABSTRACT

This chapter thoroughly examines recent breakthroughs in atopic dermatitis (AD) treatment, with a primary focus on the medications in the development pipeline. Biologics agents targeting new interleukin receptors like interleukin-31, interleukin-22, and interleukin-2 are discussed along with the novel pathway looking at the OX40-OX40L interaction. Oral agents and small molecule therapies like Janus kinase inhibitors, sphingosine-1-phosphate modulators, and Bruton's tyrosine kinase inhibitors are also discussed along with the various new topical medications. Newly approved topicals like phosphodiesterase-4 and JAK inhibitors are highlighted while also discussing the potential of tapinarof and emerging microbiome-targeted therapies. Beyond conventional approaches, the chapter touches upon unconventional therapies currently being studied. The goal of this chapter is to discuss new advances in AD treatment from medications in the initial stages of development to those nearing FDA approval.

Assuntos

Dermatite Atópica; Dermatite Atópica/tratamento farmacológico; Dermatite Atópica/terapia; Dermatite Atópica/microbiologia; Dermatite Atópica/imunologia; Humanos; Produtos Biológicos/uso terapêutico; Inibidores da Fosfodiesterase 4/uso terapêutico; Inibidores de Janus Quinases/uso terapêutico; Animais; Terapia de Alvo Molecular/métodos; Fármacos Dermatológicos/uso terapêutico

Palavras-chave

Atopic dermatitis; Clinical trials; Future management; Future treatment; Immune targets; Management; Microbiome; Monoclonal antibodies; Personalized care; Targeted treatment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dermatite Atópica Limite: Animals / Humans Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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