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Genomic Analysis of Aedes aegypti in the Northern Chihuahuan Desert of Texas and Mexico.
Vera, Adam J; Soliz, Albert G; Khatchikian, Camilo E; de la Mora-Covarrubias, Antonio; Watts, Douglas M; Lavretsky, Philip.
Afiliação
  • Vera AJ; Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
  • Soliz AG; Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
  • Khatchikian CE; Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
  • de la Mora-Covarrubias A; Department of Epidemiology/Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
  • Watts DM; Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Mexico.
  • Lavretsky P; Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Vector Borne Zoonotic Dis ; 24(10): 673-681, 2024 Oct.
Article em En | MEDLINE | ID: mdl-38717107
ABSTRACT

Background:

Aedes aegypti, is the primary vector of dengue, Chikungunya, Zika, and yellow fever viruses. Both natural and human-impacted landscapes have selective pressures on Ae. aegypti, resulting in strong genomic structure even within close geographical distances. Materials and

Methods:

We assess the genetic structure of this medically important mosquito species at the northern leading edge of their distribution in Southwestern USA. Ae. aegypti were collected during 2017 in the urban communities of El Paso and Sparks, Texas (USA) and in the city of Ciudad Juárez, Mexico.

Results:

Thousands of nuclear loci were sequenced across 260 captured Ae. aegypti. First, we recovered the genetic structure of Ae. aegypti following geography, with all four major collection communities being genetically distinct. Importantly, we found population structure and genetic diversity that suggest rapid expansion through active-short distance dispersals, with Anapra being the likely source for the others. Next, tests of selection recovered eight functional genes across six outliers calmodulin with olfactory receptor function; the protein superfamily C-type lectin with function in mosquito immune system and development; and TATA box binding protein with function in gene regulation.

Conclusion:

Despite these populations being documented in the early 2000s, we find that selective pressures on specific genes have already occurred and likely facilitate Ae. aegypti range expansion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aedes Limite: Animals País/Região como assunto: Mexico Idioma: En Revista: Vector Borne Zoonotic Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / EPIDEMIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aedes Limite: Animals País/Região como assunto: Mexico Idioma: En Revista: Vector Borne Zoonotic Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / EPIDEMIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos